| Gene Symbol | SH2D2A |
|---|---|
| Entrez Gene | 9047 |
| Alt Symbol | F2771, SCAP, TSAD, VRAP |
| Species | Human |
| Gene Type | protein-coding |
| Description | SH2 domain containing 2A |
| Other Description | SH2 domain protein 2A|SH2 domain-containing protein 2A|T cell specific adapter protein TSAd|T lymphocyte specific adaptor protein|VEGF receptor-associated protein |
| Swissprots | Q5UBZ1 O43817 Q5VZS4 Q9NP31 Q5VZS5 Q9UPA7 |
| Accessions | AAF69027 EAW52905 EAW52906 EAW52907 Q9NP31 AF051325 AAC99298 AF097744 AAF43260 AJ000553 CAA04185 AK222737 BAD96457 AK313706 BAG36451 AY763098 AAV34673 AY763099 AAV34674 AY763100 AAV34675 BC012107 AAH12107 BQ012931 DB128222 EU832614 ACE87705 EU832686 ACE87018 XM_006711615 XP_006711678 XM_011510113 XP_011508415 XM_011510114 XP_011508416 XM_011510115 XP_011508417 NM_001161441 NP_001154913 NM_001161442 NP_001154914 NM_001161443 NP_001154915 NM_001161444 NP_001154916 NM_003975 NP_003966 |
| Function | Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in unstimulated T-cells, but not expressed in normal resting or activated B-cells. According to PubMed:10692392, expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium and other cell and tissue types, such as heart, lung, and liver. |
| Top Pathways | VEGF signaling pathway |