Gene Symbol | Dkk1 |
---|---|
Entrez Gene | 13380 |
Alt Symbol | mdkk-1 |
Species | Mouse |
Gene Type | protein-coding |
Description | dickkopf homolog 1 (Xenopus laevis) |
Other Description | dickkopf-1|dickkopf-like protein 1|dickkopf-related protein 1|dkk-1 |
Swissprots | O54908 Q80UL5 |
Accessions | EDL41707 O54908 AF030433 AAC02426 AK141693 BAE24802 AK144119 BAE25711 BC050189 AAH50189 JN966751 AFI61654 NM_010051 NP_034181 |
Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. {ECO:0000269|PubMed:18524778}. |
Subcellular Location | Secreted. |
Top Pathways | Wnt signaling pathway |