IL27

Gene Symbol	IL27
Entrez Gene	246778
Alt Symbol	IL-27, IL-27A, IL27A, IL27p28, IL30, p28
Species	Human
Gene Type	protein-coding
Description	interleukin 27
Other Description	IL-27 p28 subunit|IL-27 subunit alpha|IL-27-A|IL27-A|interleukin 30|interleukin-27 subunit alpha|interleukin-30
Swissprots	Q8NEV9 Q6P676 A0N0L2
Accessions	ABK41903 CCA63967 EAW52277 Q8NEV9 AY099296 AAM34498 BC062422 AAH62422 HQ447563 ADQ32049 XM_011545780 XP_011544082 NM_145659 NP_663634
Function	Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T- helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct
Subcellular Location	Secreted {ECO:0000269|PubMed:12121660}. Note=Does not seem to be secreted without coexpression of EBI3.
Tissue Specificity	Expressed in monocytes and in placenta. {ECO:0000269|PubMed:12121660}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IL-27 (Interleukin-27) Human ELISA Kit - ab83695 from Abcam Category ELISA Kit Prices $489.00, $734.00 Sizes 1 x 96 tests, 2 x 96 tests Sensitivity < 12.8 pg/ml Range 31.25 pg/ml - 1000 pg/ml

Human IL27 ELISA Kit (Sandwich ELISA) - LS-F4189 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 15.63 pg/ml Range 157-10000 pg/ml

Rat IL27 ELISA Kit (Sandwich ELISA) - LS-F4190 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 2.9 pg/ml Range 157-10000 pg/ml

Human IL27 ELISA Kit (Sandwich ELISA) - LS-F2684 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 10 pg/ml Range 157-10000 pg/ml

Mouse IL27 ELISA Kit (Sandwich ELISA) - LS-F2685 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 157-10000 pg/ml

Mouse IL27 ELISA Kit (Sandwich ELISA) - LS-F1017 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 157-10000 pg/ml

Human IL27 ELISA Kit (Sandwich ELISA) - LS-F1000 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 157-10000 pg/ml

Human IL-27 DuoSet ELISA - DY2526 from R&D Systems Category ELISA Kit Prices $249.00, $649.00 Sizes 1 kit (for 5 Plates), 1 kit (for 15 Plates) Range 156.00 - 10,000 pg/mL

Mouse IL-27 p28/IL-30 DuoSet ELISA - DY1834 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 15.60 - 1,000 pg/mL

Mouse IL-27 p28/IL-30 Quantikine ELISA Kit - M2728 from R&D Systems Category ELISA Kit Prices $479.00 Sizes 1 kit Sensitivity 4.7 pg/mL Range 7.8 - 500 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)

Human IL-27 DuoSet, 5 Plate - DY2526-05 from R&D Systems Category ELISA Kit

Human IL27 ELISA kit - 55R-2187 from Fitzgerald Category ELISA Kit Prices $545.00 Sizes 96 tests

Mouse IL27 ELISA kit - 55R-2210 from Fitzgerald Category ELISA Kit Prices $545.00 Sizes 96 tests

Rat IL27 ELISA kit - 55R-2168 from Fitzgerald Category ELISA Kit Prices $545.00 Sizes 96 tests

IL-27 ELISA Kit (Human) : 96 Wells (OKAG00145) - OKAG00145 from Aviva Systems Biology Category ELISA Kit Prices $390.00 Sizes 96 wells Sensitivity 157 pg/mL Range 157-1,0000 pg/mL

Human IL-27 ELISA Kit - orb219442 from Biorbyt Category ELISA Kit Prices $706.00 Sizes 96 test Sensitivity 10 pg/ml Range 156 pg/ml-10000 pg/ml

Mouse IL-27 ELISA Kit - orb219719 from Biorbyt Category ELISA Kit Prices $706.00 Sizes 96 test Sensitivity 10 pg/ml Range 15.6 pg/ml-1000 pg/ml

Human IL-27 ELISA Kit - abx056228 from Abbexa Category ELISA Kit

Human Interleukin 27 ELISA Kit - abx052284 from Abbexa Category ELISA Kit

Human Interleukin 27 ELISA Kit - abx152035 from Abbexa Category ELISA Kit Sensitivity 5.9 pg/ml Range 15.625 pg/ml - 1000 pg/ml

IL-27, Human, ELISA Kit - PB-0799 from ARP American Research Products Category ELISA Kit Prices $469.00 Sizes 96 t Sensitivity < 10 pg/ml Range 156pg/ml-10000pg/ml

Interleukin 27, Human, ELISA Kit - E01I0026 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 1.0pg/ml Range 50-1000pg/mL,

Interleukin 27, IL-27, Human, ELISA Kit - CSB-E08464h from ARP American Research Products Category ELISA Kit Prices $366.00, $496.00, $497.00, $499.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.39 pg/ml Range 1.56 pg/ml-100 pg/ml

Interleukin 27, IL-27, Mouse, ELISA Kit - E-EL-M0732 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 18.75 Range 31.25-2000pg/mL

Interleukin 27, IL-27, Rat, ELISA Kit - E-EL-R0570 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 9.375 Range 15.625-1000pg/mL

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