| Gene Symbol |
Cftr
|
| Entrez Gene |
24255
|
| Alt Symbol |
RGD1561193
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
cystic fibrosis transmembrane conductance regulator
|
| Other Description |
ATP-binding cassette sub-family C member 7|ATP-binding cassette transporter sub-family C member 7|cAMP-dependent chloride channel|channel conductance-controlling ATPase|cystic fibrosis transmembrane conductance regulator homolog
|
| Swissprots |
Q2IBD3 P34158
|
| Accessions |
AAA73561 AAB24879 AAR16315 CAA65168 EDM15127 P34158 FJ959076 ADB88766 M89906 AAA40918 XM_006236097 XP_006236159 XM_008762680 XP_008760902 NM_031506 NP_113694
|
| Function |
Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Early endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000255|PROSITE- ProRule:PRU00441}. Cell membrane {ECO:0000250}. Note=In epithelial cells, detected on the apical side, but not associated with cilia. {ECO:0000250}.
|
| Top Pathways |
ABC transporters, Gastric acid secretion, Pancreatic secretion, Bile secretion, AMPK signaling pathway
|