APC2

Gene Symbol APC2
Entrez Gene 850818
Alt Symbol RSI1, TID2
Species Yeast
Gene Type protein-coding
Description anaphase promoting complex subunit 2
Other Description -
Swissprots Q12440 D6VYC2 Q2VQX4 Q7LGV7
Accessions DAA09438 Q12440 NM_001182014 NP_013228
Function Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication. {ECO:
Subcellular Location Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Top Pathways Cell cycle - yeast, Ubiquitin mediated proteolysis, Meiosis - yeast

Recombinant Saccharomyces cerevisiae Anaphase-promoting complex subunit 2(APC2) - CSB-YP614222SVG CSB-EP614222SVG CSB-BP614222SVG CSB-MP614222SVG from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Yeast

Anaphase-promoting complex subunit 2(APC2) ,partial, Recombinant Protein - MBS1406213 from MyBioSource

Category Protein
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Yeast
Search more