ATG5

Gene Symbol	ATG5
Entrez Gene	9474
Alt Symbol	APG5, APG5-LIKE, APG5L, ASP, hAPG5
Species	Human
Gene Type	protein-coding
Description	autophagy related 5
Other Description	ATG5 autophagy related 5 homolog|apoptosis-specific protein|autophagy protein 5
Swissprots	Q9H1Y0 Q9HCZ7 Q5JVR2 Q9H2B8 O60875 Q68DI4
Accessions	EAW48414 EAW48415 EAW48416 EAW48417 EAW48418 Q9H1Y0 AF293841 AAG44955 AK001899 BAG50990 AK299577 BAH13072 AK315800 BC002699 AAH02699 BC093011 AAH93011 BM831472 BP297166 BX537904 CAD97890 CR749386 CAH18236 EU283338 EU283339 ABX79918 HQ447996 ADQ32477 HY168998 JQ918353 AGC52701 JQ918354 AGC52702 JQ924061 AGC52703 Y11588 CAA72327 XM_011536263 XP_011534565 NM_001286106 NP_001273035 NM_001286107 NP_001273036 NM_001286108 NP_001273037 NM_001286111 NP_001273040 NM_004849 NP_004840 NR_104402 NR_104403
Function	Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12- ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in
Subcellular Location	Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.
Tissue Specificity	Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.
Top Pathways	RIG-I-like receptor signaling pathway, Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human APG5L/ATG5 full length protein - ab40469 from Abcam Category Protein Prices $235.00 Sizes 50 µg Source E. coli Species Human

Human APG5L/ATG5 full length protein - ab103787 from Abcam Category Protein Prices $235.00, $866.00 Sizes 50 µg, 250 µg Source E. coli Species Human

Human APG5L/ATG5 peptide - ab89372 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

APG5 / ATG5 Antibody Blocking Peptide - LS-E5602 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APG5 / ATG5 Antibody Blocking Peptide - LS-E5603 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APG5 / ATG5 Antibody Blocking Peptide - LS-E19517 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APG5 / ATG5 Antibody Blocking Peptide - LS-E21605 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APG5 / ATG5 Antibody Blocking Peptide - LS-E30436 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

APG5 / ATG5 Antibody Blocking Peptide - LS-E26846 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ATG5 Blocking Peptide - NB110-53818PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

Recombinant Human ATG5 Protein - H00009474-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Source Wheat Germ Species Human

ATG5 Partial Recombinant Protein - H00009474-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human ATG5 Protein - NBP1-50982 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 50 µg, 250 µg Source E. coli Species Human

ATG5-Antibody-C-term-Blocking-peptide - BP1812b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATG5-Antibody-N-term-Blocking-peptide - BP1812a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATG5 blocking peptide - GTX88573-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Horse, Bovine

ATG5 Protein (OPPA01361) - OPPA01361 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human ATG5 protein - orb180177 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source E.coli Species Human

Human ATG5 protein - orb80926 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

ATG5 Immunizing peptide - orb16796 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Apg5 Blocking Peptide - 33R-10975 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

ATG5 Blocking Peptide - 33R-7899 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ATG5 Blocking Peptide - 33R-2099 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ATG5 protein (His tag) - 80R-1661 from Fitzgerald Category Protein Prices $255.00 Sizes 50 µg Source E.coli

APG5/ATG5 Peptide - AC21-1677-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

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