AKR1B1

Gene Symbol AKR1B1
Entrez Gene 231
Alt Symbol ADR, ALDR1, ALR2, AR
Species Human
Gene Type protein-coding
Description aldo-keto reductase family 1, member B1 (aldose reductase)
Other Description Lii5-2 CTCL tumor antigen|aldehyde reductase 1|aldo-keto reductase family 1 member B1|aldose reductase|low Km aldose reductase
Swissprots Q6FGA4 P15121 Q9UCI9 Q9BS21 Q6ICP2 Q5U031 B2R8N3
Accessions AAA35561 AAA51712 AAB61992 AAB88851 CBX51392 EAL24070 EAW83814 EAW83815 P15121 AB209796 BAD93033 AF328729 AAN09721 AK311339 AK313439 BAG36230 AL833410 BC000260 AAH00260 BC005387 AAH05387 BC010391 AAH10391 BT019859 AAV38662 CR450351 CAG29347 CR542203 CAG47000 DQ890758 ABM81684 DQ892546 ABM83472 DQ893921 ABM84847 DQ895757 ABM86683 J04795 AAA51713 J05017 AAA51714 J05474 AAA51715 M34720 AAA35560 X15414 CAA33460 XM_005250234 XP_005250291 NM_001628 NP_001619
Function Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Subcellular Location Cytoplasm.
Tissue Specificity Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress. {ECO:0000269|PubMed:8435445}.
Top Pathways Pentose and glucuronate interconversions, Glycerolipid metabolism, Galactose metabolism, Fructose and mannose metabolism

Aldose Reductase (FL-316) - sc-33219 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Aldose Reductase (FL-316): sc-33219. Western blot analysis of Aldose Reductase expression in and Caki-1 whole cell lysate.

Aldose Reductase (C-1) - sc-271007 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Aldose Reductase (C-1): sc-271007. Western blot analysis of Aldose Reductase expression in HeLa (A), c4 (B), KNRK (C) and JAR (D) whole cell lysates.

Aldose Reductase (E-14) - sc-17736 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Aldose Reductase (E-14): sc-17736. Immunofluorescence staining of methanol-fixed Caki-1 cells showing cytoplasmic localization.

Aldose Reductase (F-10) - sc-133130 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Aldose Reductase (F-10): sc-133130. Western blot analysis of Aldose Reductase expression in Caki-1 (A), JAR (B) and KNRK (C) whole cell lysates.

Aldose Reductase (G-1) - sc-166919 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Aldose Reductase (G-1): sc-166919. Western blot analysis of Aldose Reductase expression in non-transfected: sc-117752 (A) and mouse Aldose Reductase transfected: sc-118347 (B) 293T whole cell lysates.

Aldose Reductase (H-6) - sc-166918 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Aldose Reductase (H-6): sc-166918. Western blot analysis of Aldose Reductase expression in non-transfected 293T: sc-117752 (A), mouse Aldose Reductase transfected 293T: sc-118347 (B) and JAR (C) whole cell lysates.

Aldose Reductase (N-20) - sc-17732 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Aldose Reductase (N-20): sc-17732. Immunoperoxidase staining of formalin-fixed paraffin embedded 5 um human coronary artery tissue. Kindly provided by Dr. John Sanders University of Virginia.

Aldose Reductase (P-20) - sc-17735 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Aldose Reductase (P-20): sc-17735. Western blot analysis of Aldose Reductase expression in C4 (A), RAW 264.7 (B), NIH/3T3 (C), Sol8 (D), 3T3-L1 (E) and F9 (F) whole cell lysates.

Aldose Reductase (T-15) - sc-17733 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Aldose Reductase (T-15): sc-17733. Western blot analysis of Aldose Reductase expression in Caki-1 whole cell lysate.

Anti-AKR1B1 antibody - ab62795 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-AKR1B1 antibody (ab62795) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 3 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLane 4 : Caco 2 (Human colonic carcinoma cell line) Whole Cell LysateLane 5 : Kidney (Human) Tissue Lysate - adult normal tissue (ab30203)Lane 6 : Placenta (Human) Tissue Lysate - adult normal tissue (ab29745)Lane 7 : MEL-1 (Human embryonic stem cell, male cell line) Whole Cell Lysate (ab27198)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-AKR1B1 antibody - ab175394 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human esophageal cancer tissue labelling AKR1B1 with ab175394 at 1/200. Magnification: 200x.

Anti-AKR1B1 antibody - ab71405 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-AKR1B1 antibody (ab71405) at 1/60 dilution + Jurkat cell line lysates at 35 µg

Anti-AKR1B1 antibody - ab67063 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-AKR1B1 antibody (ab67063) at 1/500 dilution + Human kidney tissue lysate at 25 µgSecondaryGoat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilution

Anti-AKR1B1 antibody - ab135906 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-AKR1B1 antibody (ab135906) at 1/500 dilution + HUVEC cell lysate at 30 µg

Anti-AKR1B1 antibody [1] - ab106189 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1
Anti-AKR1B1 antibody [1] (ab106189) at 1/1000 dilution + Jurkat cell lysate

Anti-AKR1B1 antibody [19] - ab106203 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 19
Anti-AKR1B1 antibody [19] (ab106203) at 1/1000 dilution + Jurkat whole cell lysate

Anti-AKR1B1 antibody [2D12] - ab124377 from Abcam

Prices $464.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2D12
ab124377, at 2.5 µg/ml, staining AKR1B1 in formalin fixed, paraffin embedded Human kidney (tubules) tissue by Immunohistochemistry.

Anti-AKR1B1 antibody [7] - ab106183 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7
Anti-AKR1B1 antibody [7] (ab106183) at 1/1000 dilution + Jurkat whole cell lysate

Anti-AKR1B1 antibody - C-terminal - ab71404 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-AKR1B1 antibody - C-terminal (ab71404) at 1/60 dilution + A375 cell line lysate at 35 µg

Anti-AKR1B1 / Aldose Reductase Antibody (aa201-250) - LS-C81174 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane A: Marker. Lane B: HepG2 cell lysate. Antibody concentration: 1.25 ug/ml. Gel concentration: 12%.

Anti-AKR1B1 / Aldose Reductase Antibody - LS-C109517 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate). A: 293T. B: A431. 10% SDS PAGE. AKR1B1 antibody diluted at 1:1000.

Anti-AKR1B1 / Aldose Reductase Antibody - LS-C306181 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-AKR1B1 / Aldose Reductase Antibody - LS-C309387 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AKR1B1 / Aldose Reductase Antibody (C-Terminus) - LS-C347626 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-AKR1B1 / Aldose Reductase Antibody - LS-C178285 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot detection of AKR1B1 in HT1080,MCF7,A431&Hela cell lysates using AKR1B1 antibody (1:1000 diluted).
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