| Gene Symbol |
STX4
|
| Entrez Gene |
6810
|
| Alt Symbol |
STX4A, p35-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
syntaxin 4
|
| Other Description |
renal carcinoma antigen NY-REN-31|syntaxin 4A (placental)|syntaxin-4
|
| Swissprots |
Q6FHE8 A8MXY0 Q15525 Q12846
|
| Accessions |
EAW52175 EAW52176 EAW52177 Q12846 AF026007 AAB88810 AF318489 AAG40313 AJ000541 CAA04174 AK091833 BAG52424 AK296652 BAH12411 AK315716 BAG38075 BC002436 AAH02436 BI755734 BQ775670 BT007326 AAP35990 CR541806 CAG46605 U07158 AAA20967 X85784 CAA59769 XM_005255521 XP_005255578 XM_011545925 XP_011544227 NM_001272095 NP_001259024 NM_001272096 NP_001259025 NM_004604 NP_004595
|
| Function |
Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones. {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in neutrophils and neutrophil- differentiated HL-60 cells. Expression in neutrophils increases with differentiation. {ECO:0000269|PubMed:10080545}.
|
| Top Pathways |
Vasopressin-regulated water reabsorption, SNARE interactions in vesicular transport
|
![Western Blot: Syntaxin 4 Overexpression Lysate (Adult Normal) [NBL1-16582] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Syntaxin 4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2936_Syntaxin%25204%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16582-img0002.jpg)