Aox1

Gene Symbol Aox1
Entrez Gene 11761
Alt Symbol AI196512, AI255253, Ao, Aox-1, Aox-2, Aox2, Moro, Ro
Species Mouse
Gene Type protein-coding
Description aldehyde oxidase 1
Other Description aldehyde oxidase 2|azaheterocycle hydroxylase 1|retinal oxidase
Swissprots Q9Z2Z5 Q9WU85 O54754
Accessions AAD31763 EDL00067 O54754 AB017482 BAA36834 AF076216 AAC99382 AK137697 BAE23466 BC026132 AAH26132 XM_006495630 XP_006495693 NM_009676 NP_033806
Function Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N- methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6- deoxypenciclovir to penciclovir, which is a potent antiviral agent. Also plays a role in the reductive metabolism of the xenobiotic imidacloprid (IMI) via its nitroreduction to nitrosoguanidine (IMI-NNO) and aminoguanidine (IMI-NNH(2)). Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:10377246}.
Tissue Specificity Highest expression in esophagus. Moderately low expression in lung, liver, heart, Harderian gland, olfactory mucosa, skin and testis. In brain, expression is very high in choroid plexus, high in hind brain and low in hippocampus and cerebellum. In spinal cord expression is strongest in anterior horns. Low expression detected in spleen and eye. AOX1 expression in the livers of mice is approximately seven times greater in males than females. {ECO:0000269|PubMed:10377246, ECO:0000269|PubMed:23263164, ECO:0000269|PubMed:23462233, ECO:0000269|PubMed:9243637}.
Top Pathways Tyrosine metabolism, Vitamin B6 metabolism, Nicotinate and nicotinamide metabolism, Retinol metabolism, Tryptophan metabolism

Aldehyde oxidase (AOX1), Mouse, ELISA Kit - E03A1553 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Aldehyde oxidase 1, Aox1, Mouse, ELISA Kit - E5988m from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t

Aldehyde Oxidase 1, ELISA Kit - MBS096437 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mouse Aox1 ELISA Kit - E043196 from Biobool

Category ELISA Kit

Mouse Ro ELISA Kit - E044391 from Biobool

Category ELISA Kit
Sensitivity Up to 0.5 U/L.

Mouse Ro ELISA Kit - E044392 from Biobool

Category ELISA Kit
Sensitivity 1.0 ng/mL.

Mouse Ro ELISA Kit - E044393 from Biobool

Category ELISA Kit
Sensitivity 1.0 ng/mL.

Mouse Aox2 ELISA Kit - E075374 from Biobool

Category ELISA Kit

AOX1 ELISA Kit (Mouse) (OKEH05068) - OKEH05068 from Aviva Systems Biology

Category ELISA Kit
Prices $440.00
Sizes 96 wells
Sensitivity 0.16 ng/mL
Range 0.312-20 ng/mL

Aldehyde oxidase, ELISA Kit - MBS2885185 from MyBioSource

Category ELISA Kit
Prices $380.00, $500.00, $2,170.00, $3,840.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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