ENTPD5

Gene Symbol	ENTPD5
Entrez Gene	957
Alt Symbol	CD39L4, NTPDase-5, PCPH
Species	Human
Gene Type	protein-coding
Description	ectonucleoside triphosphate diphosphohydrolase 5
Other Description	CD39 antigen-like 4|CD39-like 4|ER-UDPase|GDPase ENTPD5|NTPDase 5|Pcph proto-oncogene protein|UDPase ENTPD5|guanosine-diphosphatase ENTPD5|nucleoside diphosphatase|proto-oncogene CPH|uridine-diphosphatase ENTPD5
Swissprots	Q96RX0 O75356 A1L4C5
Accessions	EAW81149 EAW81150 EAW81151 EAW81152 EAW81153 EAW81154 EAW81155 EAW81156 O75356 AF039918 AAC39885 AF136572 AAK82950 AK025209 AY430094 AAR06666 BC020966 BC107878 BC130485 AAI30486 BC130487 AAI30488 DB017355 HQ258244 ADR82998 HQ258615 ADR83367 XM_005268221 XP_005268278 XM_005268222 XP_005268279 XM_005268224 XP_005268281 XM_006720324 XP_006720387 XM_006720325 XP_006720388 XM_006720326 XP_006720389 XM_011537385 XP_011535687 XM_011537386 XP_011535688 NM_001249 NP_001240
Function	Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling. {ECO:0000269|PubMed:10400613}.
Subcellular Location	Endoplasmic reticulum {ECO:0000250}. Secreted {ECO:0000269|PubMed:10400613}.
Tissue Specificity	Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues. {ECO:0000269|PubMed:9676430}.
Top Pathways	Purine metabolism, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ENTPD5 peptide - ab190069 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

ENTPD5 protein (His-DHFR tag) - ab127818 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

Human ENTPD5 full length protein - ab132837 from Abcam Category Protein Source Wheat germ Species Human

ENTPD5 / CD39L4 Antibody Blocking Peptide - LS-E22658 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ENTPD5 / CD39L4 Antibody Blocking Peptide - LS-E6527 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CD39L4/ENTPD5 Protein - H00000957-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CD39L4/ENTPD5 Protein - H00000957-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ENTPD5-Antibody-C-term-Blocking-Peptide - BP19295b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human CD39L4/ENTPD5, CF - 5297-EN-010 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Val21-His428 (major) & Ser46-His428 (minor), both with a C-terminal 6-His tag

Human mNTPase protein - orb138763 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Baculovirus-Insect Cells Species Human

CD39L4 / ENTPD5 - H00000957-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

CD39L4 / ENTPD5 - H00000957-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD39L4 / ENTPD5 - H00000957-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human ENTPD5, His-tagged - ENTPD5-1034H from Creative Biomart Category Protein Source CHO Cells Species Human

Human ENTPD5 Protein (His Tag) - 11184-H08B-10 from Sino Biological Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human Ectonucleoside triphosphate diphosphohydrolase 5(ENTPD5) - CSB-YP007694HU CSB-EP007694HU CSB-BP007694HU CSB-MP007694HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human CD39L4/ENTPD5 Protein, CF - 5297-EN from R&D Systems Category Protein Prices $329.00 Sizes 10 µg Source Chinese Hamster Ovary cell line, CHO-derived Val21-His428 (major) & Ser46-His428 (minor), both with a C-terminal 6-His tag Accession # O75356 Species Human

ENTPD5 Protein - abx163084 from Abbexa Category Protein Species Human

CD39L4 / ENTPD5 - TP324300 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Human ENTPD5 Protein (His tag) - PKSH031224 from Elabscience Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human ENTPD5 Protein, His-tagged - ENTPD5-301H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

CD39L4/ENTPD5 Recombinant Protein Antigen - NBP1-85751PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ENTPD5 Peptide, Human - M34GP04959H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human ENTPD5 Protein (His Tag) - 11184-H08B from ABclonal Category Protein Prices $178.00, $298.00 Sizes 10 µg, 20 µg Source Baculovirus-Insect Cells Species Human

Ectonucleoside triphosphate diphosphohydrolase 5, Recombinant Protein - MBS7042668 from MyBioSource Category Protein Prices $1,235.00, $2,220.00, $3,430.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression

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