PTGS2

Gene Symbol	PTGS2
Entrez Gene	5743
Alt Symbol	COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
Species	Human
Gene Type	protein-coding
Description	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Other Description	PGH synthase 2|PHS II|cyclooxygenase 2b|prostaglandin G/H synthase 2|prostaglandin H2 synthase 2
Swissprots	Q16876 P35354 A8K802
Accessions	AAA57317 AAD14842 AAF85977 AAN87129 AAO38056 AAQ75702 BAA05698 CBH19826 CBX54355 EAW91216 P35354 AJ634912 CAG25548 AK292167 BAF84856 AY151286 AAN52932 AY462100 AAR23927 BC013734 AAH13734 BM978796 DA277667 EU176282 ABW03733 EU176597 ABW03398 HM473188 ADJ56342 L15326 AAA35803 M90100 AAA58433 NM_000963 NP_000954
Function	Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. {ECO:0000269|PubMed:16373578}.
Subcellular Location	Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Top Pathways	Leishmaniasis, Chemical carcinogenesis, Retrograde endocannabinoid signaling, TNF signaling pathway, Ovarian steroidogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Total Cox2 Sandwich ELISA Kit - 7291 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

Human PTGS2 / COX2 / COX-2 ELISA Kit (Sandwich ELISA) - LS-F4834 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.135 ng/ml Range 0.313-20 ng/ml

Mouse PTGS2 / COX2 / COX-2 ELISA Kit (Sandwich ELISA) - LS-F5035 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 30 pg/ml Range 0.313-20 ng/ml

Rat PTGS2 / COX2 / COX-2 ELISA Kit (Sandwich ELISA) - LS-F5730 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.313-20 ng/ml

Human PTGS2 / COX2 / COX-2 ELISA Kit (Sandwich ELISA) - LS-F12319 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 1.56 ng/ml Range 0.313-20 ng/ml

Rat PTGS2 / COX2 / COX-2 ELISA Kit (Sandwich ELISA) - LS-F12320 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 1.56 Range 0.313-20 ng/ml

Mouse PTGS2 / COX2 / COX-2 ELISA Kit (Sandwich ELISA) - LS-F12321 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.313-20 ng/ml

Human/Mouse Total COX-2 DuoSet IC ELISA - DYC4198-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates) Range 156.00 - 10,000 pg/mL

Human/Mouse Total COX-2 DuoSet IC, 5 Plate - DYC4198-5 from R&D Systems Category ELISA Kit

Human/Mouse Total COX-2 Cell-Based ELISA - KCB4198 from R&D Systems Category ELISA Kit Prices $459.00 Sizes 1 kit

Rat COX2 ELISA kit - 55R-27187 from Fitzgerald Category ELISA Kit Prices $645.00 Sizes 96 wells

COX-2, Human, ELISA Kit - 27186 from ARP American Research Products Category ELISA Kit Prices $733.00 Sizes 96 t Range 1.09 ~ 70 ng/mL

Cyclooxygenase-2, COX-2, Human, ELISA Kit - CSB-E10103h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.31 ng/ml Range 1.25 ng/ml-80 ng/ml

Prostaglandin G/H synthase 2 (PTGS2), Human, ELISA Kit - E01P0882 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Prostaglandin G/H synthase 2, PTGS2, Human, ELISA Kit - E0699h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 1.56-100 ng/mL

Prostaglandin Endoperoxide Synthase 2, PTGS2/COX-2, Human, ELISA Kit - E-EL-H1846 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Prostaglandin Endoperoxide Synthase 2, PTGS2/COX-2, Mouse, ELISA Kit - E-EL-M0959 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Prostaglandin Endoperoxide Synthase 2, PTGS2/COX-2, Rat, ELISA Kit - E-EL-R0792 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 75 Range 125-8000pg/mL

Prostaglandin Endoperoxide Synthase 2, PTGS2/COX-2, Rabbit, ELISA Kit - E-EL-RB1359 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Prostaglandin Endoperoxide Synthase 2, PTGS2/COX-2, Chicken, ELISA Kit - E-EL-Ch0986 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Prostaglandin Endoperoxide Synthase 2, PTGS2/COX-2, Porcine, ELISA Kit - E-EL-P2141 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Prostaglandin Endoperoxide Synthase 2, PTGS2/COX-2, Sheep, ELISA Kit - E-EL-S0080 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Prostaglandin Endoperoxide Synthase 2, PTGS2/COX-2, Guinea Pig, ELISA Kit - E-EL-GP1246 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Prostaglandin Endoperoxide Synthase 2, PTGS2/COX-2, Monkey, ELISA Kit - E-EL-MK0910 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

PTGS2 (Human) IP-WB Antibody Pair - H00005743-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

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