| Gene Symbol |
NPPA
|
| Entrez Gene |
4878
|
| Alt Symbol |
ANF, ANP, ATFB6, ATRST2, CDD, CDD-ANF, CDP, PND
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
natriuretic peptide A
|
| Other Description |
atriopeptin|cardiodilatin|cardiodilatin-related peptide|cardionatrin|natriuretic peptide precursor A|natriuretic peptides A|prepronatriodilatin
|
| Swissprots |
Q5JZE1 P01160 Q13766
|
| Accessions |
AAA35528 AAA35529 AAB59379 ACA05916 CAA25699 CAA25700 EAW71717 P01160 AA779538 BC005893 AAH05893 DQ893115 ABM84041 DQ896389 ABM87388 EU176780 ABW03581 K02044 AAA51730 M30262 AAA35669 NM_006172 NP_006163
|
| Function |
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. {ECO:0000269|PubMed:1672777}.
|
| Subcellular Location |
Secreted.
|
![Western Blot: proANP Overexpression Lysate (Adult Normal) [NBL1-13752] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for proANP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4545_proANP%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13752-img0002.jpg)