Gene Symbol | Il34 |
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Entrez Gene | 76527 |
Alt Symbol | 2010004A03Rik, AI593503 |
Species | Mouse |
Gene Type | protein-coding |
Description | interleukin 34 |
Other Description | interleukin-34 |
Swissprots | B2ZC72 Q8R1R4 Q9D8F2 B2ZC71 |
Accessions | EDL11469 EDL11470 Q8R1R4 AK008082 BAB25448 AW743837 BC016254 AAH16254 BY148512 EU636995 ACD13453 EU636996 ACD13454 XM_006531479 XP_006531542 XM_006531480 XP_006531543 XM_006531481 XP_006531544 XM_006531482 XP_006531545 XM_006531483 XP_006531546 XM_006531484 XP_006531547 XM_006531485 XP_006531548 XM_006531486 XP_006531549 XM_011248544 XP_011246846 NM_001135100 NP_001128572 NM_029646 NP_083922 |
Function | Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted {ECO:0000250}. |
IL-34 CRISPR/Cas9 KO Plasmid (m) - sc-429354 from Santa Cruz Biotechnology
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IL-34 HDR Plasmid (m) - sc-429354-HDR from Santa Cruz Biotechnology
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IL-34 Double Nickase Plasmid (m) - sc-429354-NIC from Santa Cruz Biotechnology
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IL-34 Double Nickase Plasmid (m2) - sc-429354-NIC-2 from Santa Cruz Biotechnology
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IL-34 CRISPR Activation Plasmid (m) - sc-429354-ACT from Santa Cruz Biotechnology
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IL-34 CRISPR Activation Plasmid (m2) - sc-429354-ACT-2 from Santa Cruz Biotechnology
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IL-34 Lentiviral Activation Particles (m) - sc-429354-LAC from Santa Cruz Biotechnology
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IL-34 Lentiviral Activation Particles (m2) - sc-429354-LAC-2 from Santa Cruz Biotechnology
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IL-34 siRNA (m) - sc-146220 from Santa Cruz Biotechnology
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IL-34 shRNA Plasmid (m) - sc-146220-SH from Santa Cruz Biotechnology
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IL-34 shRNA (m) Lentiviral Particles - sc-146220-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN33798 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33798 from Sigma-Aldrich
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IL34 siRNA (Mouse) - CRM9660 from Cohesion Biosciences
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IL34 - MBS8207841 from MyBioSource
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shRNA set against Mouse IL34 (NM_029646.2) - SHH318941 from Creative biogene
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shRNA set against Mouse 2010004A03Rik(NM_001135100.1) - SHG006373 from Creative biogene
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IL34 shRNA Plasmid (Mouse) - CHM9660 from Cohesion Biosciences
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IL34 miRNA 3'UTR clone - MiUTR1M-00304 from Creative biogene
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