ELOVL4

Gene Symbol ELOVL4
Entrez Gene 6785
Alt Symbol ADMD, CT118, ISQMR, SCA34, STGD2, STGD3
Species Human
Gene Type protein-coding
Description ELOVL fatty acid elongase 4
Other Description 3-keto acyl-CoA synthase ELOVL4|ELOVL FA elongase 4|cancer/testis antigen 118|elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4|elongation of very long chain fatty acids protein 4|very-long-chain 3-oxoacyl-CoA synthase 4
Swissprots Q86YJ1 B2R6B5 Q5TCS2 Q9H139 Q9GZR5
Accessions AAG47669 EAW48701 Q9GZR5 AF277094 AAG47668 AJ420478 AK055277 BAB70895 AK310625 AK312511 BAG35412 AY037298 AAK68639 BC038506 AAH38506 DA122864 DQ426871 DQ891229 ABM82155 HQ447854 ADQ32338 NM_022726 NP_073563
Function Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development. {ECO:0000269|PubMed:20937905}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:16036915, ECO:0000269|PubMed:20937905}; Multi- pass membrane protein {ECO:0000255}.
Tissue Specificity Expressed in the retina and at much lower level in the brain. Ubiquitous, highest expression in thymus, followed by testis, small intestine, ovary, and prostate. Little or no expression in heart, lung, liver, or leukocates. {ECO:0000269|PubMed:20937905}.
Top Pathways Fatty acid elongation

ELOVL4 (H-60) - sc-67215 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ELOVL4 (H-60): sc-67215. Western blot analysis of ELOVL4 expression in mouse brain tissue extract.

ELOVL4 (Q-14) - sc-49192 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ELOVL4 (W-12) - sc-49193 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-ELOVL4 antibody - ab14922 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-ELOVL4 antibody - ab14925 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-ELOVL4 antibody - ab14924 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-ELOVL4 antibody - ab110047 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ELOVL4 antibody (ab110047) at 1/500 dilutionLane 1 : extracts from HeLa cellsLane 2 : extracts from HeLa cells with blocking peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-ELOVL4 Antibody - LS-C140571 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ELOVL4 Antibody (aa286-314, AP) - LS-C259256 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ELOVL4 Antibody (aa286-314, FITC) - LS-C259260 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ELOVL4 Antibody (aa286-314, Biotin) - LS-C259259 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ELOVL4 Antibody (aa286-314, Azide-free, HRP) - LS-C259261 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ELOVL4 Antibody (aa285-314) - LS-C321097 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ELOVL4 Antibody (aa286-314, PE) - LS-C259262 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ELOVL4 Antibody - LS-C140625 from LifeSpan Bioscience

Prices $460.00
Sizes 10 blot
Host Rabbit
Clonality Polyclonal
IHC of normal human testis tissue using ELOV4 antibody (LS-C140625) at 15 ug/ml.

Anti-ELOVL4 Antibody (aa41-90) - LS-C119953 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HeLa cells, using ELOVL4 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-ELOVL4 Antibody (aa286-314) - LS-C167737 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ELOVL4 Antibody western blot of 293 cell line lysates (35 ug/lane). The ELOVL4 antibody detected the ELOVL4 protein (arrow).

Anti-ELOVL4 Antibody - LS-C332691 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of Y79 cell line, using ELOVL4 antibody.

Anti-ELOVL4 Antibody (aa286-314, APC) - LS-C259258 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

ELOVL4 Antibody - NBP1-68493 from Novus Biologicals

Prices $229.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: ELOVL4 Antibody [NBP1-68493] - Analysis of extracts from HeLa cells, using ELOVL4 Antibody. The lane on the right is treated with the synthesized peptide.

ELOVL4 Antibody - H00006785-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-ELOVL4 antibody produced in rabbit - SAB4502884 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-ELOVL4: <B>Cat. No. SAB4502884</B>: Immunoblotting analysis of extracts from HeLa cells, using Anti-ELOVL4 antibody. The lane on the left was treated with the Anti-ELOVL4 antibody. The lane on the right (negative control) was treated with both Anti-ELOVL4 antibody and the synthesized immunogen peptide.

ANTI-ELOVL4 (C-TERM) antibody produced in rabbit - SAB1304888 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-ELOVL4 (C-term): <B>Cat. No. SAB1304888</B>: ELOVL4 Antibody (C-term) western blot analysis in HEK_293 cell line lysates (35 μg/lane).

Anti-ELOVL4 antibody produced in rabbit - SAB4300769 from Sigma-Aldrich

Prices $230.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-ELOVL4: <B>Cat. No. SAB4300769</B>: Western blot analysis of extracts from HeLa cells using Anti-ELOVL4 antibody. The lane on the right is treated with the synthesized peptide.

ELOVL4-Antibody-C-term - AP16326b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
ELOVL4 Antibody (C-term) (Cat. #AP16326b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ELOVL4 antibody detected the ELOVL4 protein (arrow).
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