Lrp6

Gene Symbol Lrp6
Entrez Gene 16974
Alt Symbol C030016K15Rik, Cd, Gw, ska26, ska<m26Jus>, skax26
Species Mouse
Gene Type protein-coding
Description low density lipoprotein receptor-related protein 6
Other Description LRP-6|crooked|low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6|low density lipoprotein-related protein 6|low-density lipoprotein receptor-related protein 6
Swissprots O88572
Accessions EDL10517 O88572 AF074265 AAC33007 AK021086 AK140796 BAE24482 AK162203 BAE36789 BC060704 AAH60704 CJ124877 CO042145 XM_006505657 XP_006505720 NM_008514 NP_032540
Function Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250}.
Subcellular Location Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Note=On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes (By similarity). Chaperoned to the plasma membrane by MESD. {ECO:0000250}.
Tissue Specificity Expressed in early embryo. Broadly expressed throughout the embryonic ectoderm and in nascent mesoderm, and in endoderm emerging from the primitive streak. {ECO:0000269|PubMed:15142971}.
Top Pathways Wnt signaling pathway

Low-density lipoprotein receptor-related protein 6, Lrp6, Mouse, ELISA Kit - E1010m from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t
Range 0.625-40 ng/mL

Mouse LRP6 ELISA Kit - ML0286 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

Lrp6 - EKM0980 from Nordic BioSite

Sensitivity 0.375ng/ml
Range 0.625-40ng/ml

Lrp6 - EKM980 from Nordic BioSite

Sensitivity 0.375ng/ml
Range 0.625-40ng/ml

Mouse LRP6 ELISA Kit - E058982 from Biobool

Category ELISA Kit

LRP6 ELISA Kit (Mouse) (OKEH03262) - OKEH03262 from Aviva Systems Biology

Category ELISA Kit
Prices $425.00
Sizes 96 wells
Sensitivity 0.3125 ng/mL
Range 0.625 - 40 ng/mL

Mouse LRP6 ELISA Kit - EML0286 from ABclonal

Category ELISA Kit
Prices $495.00
Sizes 96 t

Mouse Low-density lipoprotein receptor-related protein 6 ELISA Kit - EK2529 from Signalway Antibody

Category ELISA Kit
Prices $599.00
Sizes 1x96t
Range 0.625-40 ng/mL

Low-density lipoprotein receptor-related protein 6, ELISA Kit - MBS9426368 from MyBioSource

Category ELISA Kit
Prices $555.00
Sizes 96 tests
Range 0.625-40 ng/mL

Low-density lipoprotein receptor-related protein 6, ELISA Kit - MBS2882801 from MyBioSource

Category ELISA Kit
Prices $380.00, $500.00, $2,170.00, $3,840.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Range 0.625-40 ng/mL

Low-Density Lipoprotein-Receptor-Related Protein 6 (LRP6), ELISA Kit - MBS9375705 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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