| Gene Symbol | CPT1A |
|---|---|
| Entrez Gene | 1374 |
| Alt Symbol | CPT1, CPT1-L, L-CPT1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | carnitine palmitoyltransferase 1A (liver) |
| Other Description | CPT I|CPTI-L|carnitine O-palmitoyltransferase 1, liver isoform|carnitine O-palmitoyltransferase I, liver isoform|carnitine palmitoyltransferase I, liver |
| Swissprots | Q9BWK0 Q8TCU0 P50416 |
| Accessions | CAD12625 CAD59673 EAW74721 EAW74722 P50416 AA632225 AJ420378 CAD12576 AK025307 AK172798 AK309464 AK314301 BAG36955 BC000185 AAH00185 BT009791 AAP88793 DB063502 L39211 AAC41748 X83113 XM_005273762 XP_005273819 XM_005273763 XP_005273820 NM_001031847 NP_001027017 NM_001876 NP_001867 |
| Function | Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism. |
| Subcellular Location | Mitochondrion outer membrane {ECO:0000269|PubMed:11350182, ECO:0000269|PubMed:14517221}; Multi- pass membrane protein {ECO:0000269|PubMed:11350182, ECO:0000269|PubMed:14517221}. |
| Tissue Specificity | Strong expression in kidney and heart, and lower in liver and skeletal muscle. |
| Top Pathways | Adipocytokine signaling pathway, PPAR signaling pathway, AMPK signaling pathway, Glucagon signaling pathway, Fatty acid degradation |