CPT1A

Gene Symbol	CPT1A
Entrez Gene	1374
Alt Symbol	CPT1, CPT1-L, L-CPT1
Species	Human
Gene Type	protein-coding
Description	carnitine palmitoyltransferase 1A (liver)
Other Description	CPT I\|CPTI-L\|carnitine O-palmitoyltransferase 1, liver isoform\|carnitine O-palmitoyltransferase I, liver isoform\|carnitine palmitoyltransferase I, liver
Swissprots	Q9BWK0 Q8TCU0 P50416
Accessions	CAD12625 CAD59673 EAW74721 EAW74722 P50416 AA632225 AJ420378 CAD12576 AK025307 AK172798 AK309464 AK314301 BAG36955 BC000185 AAH00185 BT009791 AAP88793 DB063502 L39211 AAC41748 X83113 XM_005273762 XP_005273819 XM_005273763 XP_005273820 NM_001031847 NP_001027017 NM_001876 NP_001867
Function	Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism.
Subcellular Location	Mitochondrion outer membrane {ECO:0000269\|PubMed:11350182, ECO:0000269\|PubMed:14517221}; Multi- pass membrane protein {ECO:0000269\|PubMed:11350182, ECO:0000269\|PubMed:14517221}.
Tissue Specificity	Strong expression in kidney and heart, and lower in liver and skeletal muscle.
Top Pathways	Adipocytokine signaling pathway, PPAR signaling pathway, AMPK signaling pathway, Glucagon signaling pathway, Fatty acid degradation

CPT1A (D3B3) Rabbit mAb - 12252 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	D3B3

Western blot analysis of extracts from HeLa, PANC-1, and MCF7 cells using CPT1A (D3B3) Rabbit mAb.

CPTI (N-17) - sc-20514 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CPTI-L (C-14) - sc-20516 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CPTI-L (H-95) - sc-20669 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

CPTI-L (H-95): sc-20669. Western blot analysis of CPTI-L expression in Y79 whole cell lysate.

CPTI-L (L-12) - sc-20515 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-CPT1A antibody - ab53532 from Abcam

Prices	$378.00
Sizes	200 µl
Host	Goat
Clonality	Polyclonal

ab53532 antibody (0.1µg/ml) staining of CPT1A in Human Liver lysate (35µg protein in RIPA buffer).

Anti-CPT1A antibody - ab115269 from Abcam

Prices	$384.00
Sizes	50 µg
Host	Goat
Clonality	Polyclonal

Anti-CPT1A antibody (ab115269) at 0.1 µg/ml + Human liver lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-CPT1A antibody - ab102679 from Abcam

Prices	$376.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CPT1A antibody (ab102679) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-CPT1A antibody [8F6AE9] - ab128568 from Abcam

Prices	$390.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	8F6AE9

All lanes : Anti-CPT1A antibody [8F6AE9] (ab128568) at 1 µg/mlLane 1 : MarkerLane 2 : Partial Human Recombinant CPT1A protein (ab128569) at 0.1 µgLane 3 : Full Length Human Recombinant OTC protein at 0.1 µgLane 4 : HepG2 (Human hepatocellular carcinoma cell line) Whole Cell Lysate at 20 µgLane 5 : H9C2 (Rat cardiomyoblast cell line) Whole Cell Lysate at 20 µgLane 6 : H4IIE ( Rat hepatoma cell line) Whole Cell Lysate at 20 µgLane 7 : RHM (Rat heart mitochondrial homogenate) at 20 µgLane 8 : HLH (Human liver homogenate) at 20 µgLane 9 : RLH (Rat liver homogenate) at 20 µgLane 10 : MLH (Mouse liver homogenate) at 20 µgSecondaryGoat polyclonal to Mouse IgG – H&L – Pre-Adsorbed (HRP) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CPT1A antibody [8F6AE9] (Alexa Fluor® 488) - ab171449 from Abcam

Prices	$431.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	8F6AE9

Flow cytometric analysis of HeLa cells (4% paraformaldehyde-fixed; methanol-permeablized) labeling CPT1A with ab171449 at 5 µg/mL (green) compared with an isotype control ab170192 at 5 µg/mL (black). Isotype control was labeled with a Goat Anti-mouse Alexa Fluor® 488 secondary antibody prior to signal measurement on the FL-1 channel.

Anti-CPT1A antibody [8F6AE9] (HRP) - ab198494 from Abcam

Prices	$425.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	8F6AE9

IHC image of CPT1A staining in a section of formalin-fixed paraffin-embedded normal human colon tissue*, performed on a Leica BOND. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20mins. The section was then incubated with ab198494 at 1/100 dilution, for 15 mins at room temperature. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. The inset negative control image is taken from an identical assay without primary antibody.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.*Tissue obtained from the Human Research Tissue Bank, supported by the NIHR Cambridge Biomedical Research Centre

Anti-CPT1A antibody [EPR12740(B)] - ab176320 from Abcam

Prices	$385.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR12740(B)

Flow cytometric analysis of permeabilized HeLa cells labeling CPT1A using ab176320 at a 1/10 dilution (red) or a rabbit IgG control (green).

Anti-CPT1A antibody - Carboxyterminal end - ab71466 from Abcam

Prices	$376.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CPT1A antibody - Carboxyterminal end (ab71466) at 1/100 dilution + Y79 cell line lysate at 35 µg

Anti-CPT1 / CPT1A Antibody (C-Terminus) - LS-C12433 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CPT1 / CPT1A Antibody (C-Terminus) - LS-C12432 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CPT1 / CPT1A Antibody (C-Terminus) - LS-C112689 from LifeSpan Bioscience

Host	Goat
Clonality	Polyclonal

Anti-CPT1 / CPT1A Antibody (aa727-756, AP) - LS-C255378 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CPT1 / CPT1A Antibody (aa727-756, APC) - LS-C255379 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CPT1 / CPT1A Antibody (aa684-733) - LS-C102140 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CPT1 / CPT1A Antibody (aa727-756, FITC) - LS-C255380 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CPT1 / CPT1A Antibody (aa727-756, Biotin) - LS-C255381 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CPT1 / CPT1A Antibody (aa727-756, Azide-free, HRP) - LS-C255382 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CPT1 / CPT1A Antibody (aa727-756, PE) - LS-C255383 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CPT1 / CPT1A Antibody (C-Terminus, AP) - LS-C276457 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CPT1 / CPT1A Antibody (C-Terminus, APC) - LS-C276458 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

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