| Gene Symbol |
DAPK3
|
| Entrez Gene |
1613
|
| Alt Symbol |
DLK, ZIP, ZIPK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
death-associated protein kinase 3
|
| Other Description |
DAP kinase 3|DAP-like kinase|MYPT1 kinase|ZIP-kinase|zipper-interacting protein kinase
|
| Swissprots |
B3KQE2 Q05JY4 O43293 A0AVN4
|
| Accessions |
CAF85967 EAW69276 O43293 AB007144 BAA24955 AB022341 BAA81746 AB265224 BAF34614 AI654829 AK027590 BAG51355 AK074799 BAG52004 AK093792 BAG52765 AK097643 BC126430 AAI26431 BC126432 AAI26433 DA748997 HQ258253 ADR83007 HY104892 XM_005259508 XP_005259565 NM_001348 NP_001339
|
| Function |
Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase- dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers i
|
| Subcellular Location |
Isoform 2: Nucleus {ECO:0000269|PubMed:17126281}. Cytoplasm {ECO:0000269|PubMed:17126281}.
|
| Tissue Specificity |
Widely expressed. Isoform 1 and isoform 2 are expressed in the bladder smooth muscle. {ECO:0000269|PubMed:15292222, ECO:0000269|PubMed:17126281}.
|
| Top Pathways |
Bladder cancer
|