| Gene Symbol | AP2M1 |
|---|---|
| Entrez Gene | 1173 |
| Alt Symbol | AP50, CLAPM1, mu2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | adaptor-related protein complex 2, mu 1 subunit |
| Other Description | AP-2 complex subunit mu|AP-2 mu 2 chain|AP-2 mu chain|HA2 50 kDA subunit|adapter-related protein complex 2 mu subunit|adapter-related protein complex 2 subunit mu|adaptin-mu2|adaptor protein complex AP-2 subunit mu|adaptor-related protein complex 2 subunit mu|clathrin adaptor complex AP2, mu subunit|clathrin assembly protein complex 2 medium chain|clathrin assembly protein complex 2 mu medium chain|clathrin coat adaptor protein AP50|clathrin coat assembly protein AP50|clathrin coat-associated protein AP50|clathrin-associated/assembly/adaptor protein, medium 1|plasma membrane adaptor AP-2 50 kDa protein|plasma membrane adaptor AP-2 50kDA protein |
| Swissprots | D3DNT1 A6NE12 Q96CW1 |
| Accessions | CAR81017 CBX84495 EAW78290 EAW78291 EAW78292 Q96CW1 AK057883 AK294159 BAG57482 AK295999 BAG58773 AK297578 BAH12618 AK297849 BAG60181 AK300228 BAG61996 AK304510 BAG65316 AK310409 BC004996 AAH04996 BC013796 AAH13796 BC014030 AAH14030 BI461415 BT007308 AAP35972 D63475 BAA09762 DQ892876 ABM83802 DQ895915 ABM86841 U36188 AAA93254 NM_001025205 NP_001020376 NM_004068 NP_004059 |
| Function | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to p |
| Subcellular Location | Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250}. |
| Top Pathways | Huntington's disease, Endocytosis, Endocrine and other factor-regulated calcium reabsorption, Synaptic vesicle cycle |