| Gene Symbol |
MAML1
|
| Entrez Gene |
9794
|
| Alt Symbol |
Mam-1, Mam1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mastermind-like 1 (Drosophila)
|
| Other Description |
mastermind homolog|mastermind-like protein 1
|
| Swissprots |
Q9NZ12 Q92585
|
| Accessions |
EAW53801 Q92585 AA975821 AB209135 BAD92372 AF221759 AAF34658 AK295139 BAH11986 BC047937 D83785 BAA12114 NM_014757 NP_055572
|
| Function |
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}.
|
| Subcellular Location |
Nucleus speckle {ECO:0000269|PubMed:11101851}. Note=Nuclear, in a punctate manner.
|
| Tissue Specificity |
Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen. {ECO:0000269|PubMed:11101851}.
|
| Top Pathways |
Notch signaling pathway
|