| Gene Symbol | MTHFS |
|---|---|
| Entrez Gene | 10588 |
| Alt Symbol | HsT19268 |
| Species | Human |
| Gene Type | protein-coding |
| Description | 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) |
| Other Description | 5-formyltetrahydrofolate cyclo-ligase|methenyl-THF synthetase |
| Swissprots | H3BQ75 P49914 |
| Accessions | EAW99132 P49914 AK054972 AL109717 AL110101 BC012417 AAH12417 BC019921 AAH19921 BC037852 BM313547 BM450865 CB995322 CK905549 DB464304 HG507300 L38928 AAC41945 NM_001199758 NP_001186687 NM_006441 NP_006432 NR_037654 |
| Function | Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate. {ECO:0000269|PubMed:8522195}. |
| Subcellular Location | Cytoplasm. |
| Top Pathways | One carbon pool by folate |