NCSTN

Gene Symbol NCSTN
Entrez Gene 23385
Alt Symbol ATAG1874
Species Human
Gene Type protein-coding
Description nicastrin
Other Description anterior pharynx-defective 2
Swissprots Q92542 Q86VV5 Q5T207 Q5T208
Accessions EAW52720 EAW52721 EAW52722 Q92542 AF240468 AAG11412 AK296153 BAG58892 AK299142 BAG61194 AK310741 AK314764 BAG37302 AY359120 AAQ89478 BC047621 AAH47621 BC100024 CN429672 D87442 BAA13383 JF432369 ADZ15586 XM_005245053 XP_005245110 XM_011509363 XP_011507665 XM_011509364 XP_011507666 NM_001290184 NP_001277113 NM_001290186 NP_001277115 NM_015331 NP_056146
Function Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Subcellular Location Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:11396676}.
Top Pathways Notch signaling pathway, Alzheimer's disease

Nicastrin Antibody - 3632 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from human (HeLa and SK-N-MC; lanes 1 and 2), monkey (COS; lane 3), mouse (Neuro 2A and L; lanes 4 and 5) and rat (PC12 and C6; lanes 6 and 7) cell lines, using Nicastrin Antibody.

Nicastrin (D65G7) Rabbit mAb - 9447 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D65G7
Western blot analysis of extracts from NIH/3T3 and CAD cells using Nicastrin (D65G7) Rabbit mAb.

Nicastrin (D38F9) Rabbit mAb - 5665 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D38F9
Western blot analysis of extracts from various cell lines using Nicastrin (D38F9) Rabbit mAb.

nicastrin (F-3) - sc-377214 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
nicastrin (F-3): sc-377214. Western blot analysis of nicastrin expression in non-transfected 293T: sc-117752 (A), mouse nicastrin transfected 293T: sc-122058 (B), HeLa (C) and SK-N-SH (D) whole cell lysates.

nicastrin (B-3) - sc-376513 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
nicastrin (B-3): sc-376513. Western blot analysis of nicastrin expression in SK-N-SH (A) and HeLa (B) whole cell lysates.

nicastrin (N-19) - sc-14369 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
nicastrin (N-19): sc-14369. Western blot analysis of nicastrin expression in HeLa (A) and H4 (B) whole cell lysates.

nicastrin (D-1) - sc-376379 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
nicastrin (D-1): sc-376379. Western blot analysis of nicastrin expression in SK-N-SH (A) and HeLa (B) whole cell lysates.

nicastrin (H-300) - sc-25648 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
nicastrin (H-300): sc-25648. Western blot analysis of nicastrin expression in HeLa (A), SH-SY5Y (B), H4 (C), SK-N-SH (D) and IMR-32 (E) whole cell lysates.

nicastrin (35) - sc-136003 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/500 µl
Host Mouse
Clonality Monoclonal
nicastrin (35): sc-136003. Western blot analysis of nicastrin expression in WI 38 whole cell lysate.

Anti-Nicastrin antibody - ab45425 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Nicastrin antibody (ab45425) at 0.5 µg/mlLane 2 : Anti-Nicastrin antibody (ab45425) at 1 µg/mlLane 1 : Mouse brain tissue lysateLane 2 : Mouse brain tissue lysateLysates/proteins at 15 µg per lane.Secondaryanti-rabbit HRP at 1/10000 dilution

Anti-Nicastrin antibody - ab122969 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Nicastrin antibody (ab122969) at 1 µg/mlLane 1 : E10 Mouse Embryo Brain Tissue LysateLane 2 : E12 Mouse Embryo Brain and Spinal Cord Tissue LysateLane 3 : E16 Mouse Embryo Brain Tissue LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Nicastrin antibody - ab3444 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Nicastrin antibody - ab172419 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-Nicastrin antibody (ab172419) at 1/500 dilutionLane 1 : Nicastrin transfected lysateLane 2 : Non-transfected lysateLysates/proteins at 15 µl per lane.

Anti-Nicastrin antibody - ab78203 from Abcam

Host Mouse
Clonality Monoclonal

Anti-Nicastrin antibody [EPR2574] - ab108993 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2574
All lanes : Anti-Nicastrin antibody [EPR2574] (ab108993) at 1/1000 dilutionLane 1 : A431 cell lysateLane 2 : Jurkat cell lysateLane 3 : HeLa cell lysateLane 4 : 293T cell lysateLysates/proteins at 10 µg per lane.

Anti-Nicastrin antibody [EPR2575Y] - ab68145 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2575Y
All lanes : Anti-Nicastrin antibody [EPR2575Y] (ab68145) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : HL-60 cell lysateLane 3 : Jurkat cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP conjugated Goat anti-Rabbit at 1/2000 dilution

Anti-Nicastrin antibody - C-terminal - ab189160 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Nicastrin antibody - C-terminal (ab189160) at 0.5 µg/mlLane 2 : Anti-Nicastrin antibody - C-terminal (ab189160) at 1 µg/mlLane 3 : Anti-Nicastrin antibody - C-terminal (ab189160) at 2 µg/mlLane 1 : Mouse brain tissue lysateLane 2 : Mouse brain tissue lysateLane 3 : Mouse brain tissue lysate

Anti-Nicastrin antibody - Carboxyterminal end - ab62508 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Nicastrin antibody - Carboxyterminal end (ab62508) at 0.5 µg/mlLane 2 : Anti-Nicastrin antibody - Carboxyterminal end (ab62508) at 1 µg/mlLane 3 : Anti-Nicastrin antibody - Carboxyterminal end (ab62508) at 2 µg/mlLane 1 : Mouse brain lysateLane 2 : Mouse brain lysateLane 3 : Mouse brain lysateLysates/proteins at 15 µg per lane.

Rabbit Polyclonal to Nicastrin - ab189125 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of Human brain cells labeling Nicastrin with ab189125 at 20 µg/ml.

Anti-NCSTN / Nicastrin Antibody (C-Terminus) IHC-plus™ - LS-B530 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NCSTN / Nicastrin antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B530 concentration 10 ug/ml.

Anti-NCSTN / Nicastrin Antibody (clone AT3B2) IHC-plus™ - LS-B3583 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone AT3B2
Anti-NCSTN / Nicastrin antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3583 concentration 5 ug/ml.

Anti-NCSTN / Nicastrin Antibody (C-Terminus) - LS-C25766 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NCSTN / Nicastrin Antibody (C-Terminus) - LS-C25767 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NCSTN / Nicastrin Antibody (aa34-153) - LS-C131051 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-NCSTN / Nicastrin Antibody (C-Terminus) - LS-C152950 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
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