| Gene Symbol |
GCDH
|
| Entrez Gene |
2639
|
| Alt Symbol |
ACAD5, GCD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glutaryl-CoA dehydrogenase
|
| Other Description |
glutaryl-CoA dehydrogenase, mitochondrial|glutaryl-Coenzyme A dehydrogenase
|
| Swissprots |
O14719 A8K2Z2 Q92947
|
| Accessions |
AAB51174 AAC52079 AER00473 EAW84324 EAW84325 EAW84326 Q92947 AK098370 AK290407 BAF83096 AK296446 BAG59097 AK298772 BAG60914 AK300841 BAG62492 AK309892 AU135567 BC002579 AAH02579 BM855466 BT006706 AAP35352 DA286320 S77773 AAB34724 U69141 AAB08455 XM_006722721 XP_006722784 XM_011527899 XP_011526201 XM_011527900 XP_011526202 NM_000159 NP_000150 NM_013976 NP_039663 NR_102316 NR_102317
|
| Function |
Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive. {ECO:0000269|PubMed:17176108, ECO:0000269|PubMed:6423663, ECO:0000269|PubMed:8541831}.
|
| Subcellular Location |
Mitochondrion matrix.
|
| Tissue Specificity |
Isoform 1 and isoform 2 are expressed in fibroblasts and liver.
|
| Top Pathways |
Lysine degradation, Fatty acid degradation, Tryptophan metabolism
|
![Western Blot: GCDH Overexpression Lysate (Adult Normal) [NBP2-07400] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GCDH.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4875_GCDH%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07400-img0001.jpg)
![Western Blot: GCDH Overexpression Lysate (Adult Normal) [NBP2-09856] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GCDH.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2861_GCDH%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-09856-img0001.jpg)