| Gene Symbol |
CX3CL1
|
| Entrez Gene |
6376
|
| Alt Symbol |
ABCD-3, C3Xkine, CXC3, CXC3C, NTN, NTT, SCYD1, fractalkine, neurotactin
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-X3-C motif) ligand 1
|
| Other Description |
C-X3-C motif chemokine 1|CX3C membrane-anchored chemokine|fractalkine|small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin)|small inducible cytokine subfamily D (Cys-X3-Cys), member-1|small-inducible cytokine D1
|
| Swissprots |
P78423 O00672
|
| Accessions |
AAC24307 ABK41928 EAW82919 P78423 AB209037 BAD92274 AK222692 BAD96412 AK223351 BAD97071 AK313806 BAG36542 BC001163 AAH01163 BC016164 AAH16164 CA396869 CR457426 CAG33707 DQ890704 ABM81630 DQ891871 ABM82797 DQ893888 ABM84814 DQ895059 ABM85985 GU047346 HY114023 U84487 AAB49679 U91835 AAB50014 NM_001304392 NP_001291321 NM_002996 NP_002987
|
| Function |
The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. {ECO:0000269|PubMed:21829356}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Chemokine signaling pathway, TNF signaling pathway
|