LSS

Gene Symbol LSS
Entrez Gene 4047
Alt Symbol OSC
Species Human
Gene Type protein-coding
Description lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
Other Description 2,3-epoxysqualene--lanosterol cyclase|2,3-epoxysqualene-lanosterol cyclase|hOSC|lanosterol synthase|oxidosqualene--lanosterol cyclase
Swissprots Q9UEZ1 Q8IYL6 G5E9Q9 B4DJZ9 D3DSN0 E9PEI9 P48449
Accessions CAB42828 CAY34695 CBG17604 CBG17696 CBV30957 CBV31050 EAX09299 EAX09300 EAX09301 EAX09302 EAX09303 P48449 AA922470 AK092334 BAC03865 AK096769 BAC04859 AK098352 BAC05289 AK128839 BAC87638 AK226141 AK296313 BAG59011 AK312489 BAG35391 AY927524 BC035638 AAH35638 BM662957 BU728696 BX443698 D63807 BAA09875 DA333499 DQ891234 ABM82160 DQ894418 ABM85344 S81221 AAB36220 X87809 CAA61078 XM_006724004 XP_006724067 XM_011529564 XP_011527866 XM_011529565 XP_011527867 XM_011529566 XP_011527868 XM_011529567 XP_011527869 XR_937491 NM_001001438 NP_001001438 NM_001145436 NP_001138908 NM_001145437 NP_001138909 NM_002340 NP_002331
Function Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. {ECO:0000269|PubMed:7639730}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:14766201, ECO:0000269|PubMed:15525992}; Peripheral membrane protein {ECO:0000269|PubMed:14766201, ECO:0000269|PubMed:15525992}.
Top Pathways Steroid biosynthesis

OSC (N-20) - sc-83295 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
OSC (N-20): sc-83295. Western blot analysis of OSC expression in non-transfected: sc-117752 (A) and human OSC transfected: sc-115371 (B) 293T whole cell lysates.

OSC (G-6) - sc-365129 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
OSC (G-6): sc-365129. Western blot analysis of OSC expression in JAR whole cell lysate.

OSC (H-300) - sc-292784 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
OSC (H-300): sc-292784. Western blot analysis of OSC expression in non-transfected: sc-117752 (A) and human OSC transfected: sc-170591 (B) 293T whole cell lysates.

OSC (G-18) - sc-83294 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
OSC (G-18): sc-83294. Western blot analysis of OSC expression in non-transfected 293T: sc-117752 (A), human OSC transfected 293T: sc-115371 (B) and HeLa (C) whole cell lysates and mouse liver tissue extract (D).

Anti-LSS antibody [EPR6703] - ab140124 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6703
All lanes : Anti-LSS antibody [EPR6703] (ab140124) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Human fetal liver lysateLysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP at 1/2000 dilution

Anti-LSS antibody [EPR6704(B)] - ab124785 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6704(B)
All lanes : Anti-LSS antibody [EPR6704(B)] (ab124785) at 1/50000 dilutionLane 1 : SH-SY5Y cell lysateLane 2 : HeLa cell lysateLane 3 : HT-1376 cell lysateLane 4 : Human fetal liver lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP labelled goat anti-rabbit at 1/2000 dilution

Anti-LSS Antibody (aa101-250, Biotin) - LS-C297198 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LSS Antibody (aa388-549, Biotin) - LS-C301252 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LSS Antibody (aa388-549, FITC) - LS-C302208 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LSS Antibody (N-Terminus) - LS-C80464 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal liver lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-LSS Antibody (aa101-250, FITC) - LS-C304629 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LSS Antibody (aa470-519) - LS-C80465 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal liver lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-LSS Antibody (aa388-549) - LS-C295743 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant LSS.

Anti-LSS Antibody (clone 2E4) - LS-C133906 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E4
Immunoperoxidase of monoclonal antibody to LSS on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml]

Anti-LSS Antibody (aa101-250) - LS-C295745 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant LSS.

Anti-LSS Antibody (Internal, clone EPR6704(B)) - LS-C138819 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6704(B)
IHC of paraffin-embedded human kidney tissue using anti-LSS antibody.

LSS Antibody - NBP1-53166 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: LSS Antibody [NBP1-53166] - Human Liver cell lysate, concentration 0.2-1 ug/ml.

LSS Antibody - NBP1-82474 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: LSS Antibody [NBP1-82474] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

LSS Antibody - NBP2-33966 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: LSS Antibody [NBP2-33966] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11Lane 2: Human cell line RT-4Lane 3: Human cell line U-251 MGLane 4: Human plasmaLane 5: Human Liver tissueLane 6: Human Tonsil tissue

LSS Antibody - NBP2-17184 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: LSS Antibody [NBP2-17184] - Sample (30 ug of whole cell lysate) A: U87-MG 7. 5% SDS PAGE gel, diluted at 1:1000.

LSS Antibody (2E4.) - H00004047-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E4.
Immunocytochemistry/Immunofluorescence: LSS Antibody (2E4) [H00004047-M01] - Analysis of monoclonal antibody to LSS on HeLa cell. Antibody concentration 10 ug/ml.

Anti-LSS antibody produced in rabbit - HPA032062 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-LSS: <B>Cat. No. HPA032062</B>: Immunohistochemical staining of Human prostate shows strong granular cytoplasmic positivity in glandular cells.

Anti-LSS antibody produced in rabbit - HPA032060 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-LSS: <B>Cat. No. HPA032060</B>: Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes.

Anti-LSS (AB1) antibody produced in rabbit - AV41839 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: fetal liver (<B>Cat. No. AV41839</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1 μg/mL in cell type fetal liver

Monoclonal Anti-LSS, (C-terminal) antibody produced in mouse - SAB1402256 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E4
<B>Immunohistochemistry</B><BR/>Monoclonal Anti-LSS, antibody produced in mouse, clone 2E4, purified immunoglobulin: <B>Cat. No. SAB1402256</B>: Antibody concentration: 3 μg/mL using human placenta tissue.
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