ARSB

Gene Symbol ARSB
Entrez Gene 411
Alt Symbol ASB, G4S, MPS6
Species Human
Gene Type protein-coding
Description arylsulfatase B
Other Description N-acetylgalactosamine-4-sulfatase
Swissprots P15848 Q9UDI9 B2RC20 Q8N322
Accessions AAB19988 CAA51272 EAW95821 EAW95822 EAW95823 P15848 AI244301 AI457798 AI821478 AK026942 AK290865 BAF83554 AK314903 BAG37417 AL135624 AW236748 BC029051 AAH29051 BC036609 BM664932 BQ216635 BQ775217 BX350102 BX364854 BX369127 J05225 AAA51784 M32373 AAA51779 XM_005248506 XP_005248563 XM_006714615 XP_006714678 XM_011543390 XP_011541692 XM_011543391 XP_011541693 XM_011543392 XP_011541694 XM_011543393 XP_011541695 NM_000046 NP_000037 NM_198709 NP_942002
Function Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). {ECO:0000250|UniProtKB:P50430, ECO:0000269|PubMed:19306108}.
Subcellular Location Lysosome. Cell surface {ECO:0000250|UniProtKB:P50429}.
Top Pathways Lysosome, Glycosaminoglycan degradation