TP53BP2

Gene Symbol TP53BP2
Entrez Gene 7159
Alt Symbol 53BP2, ASPP2, BBP, P53BP2, PPP1R13A
Species Human
Gene Type protein-coding
Description tumor protein p53 binding protein 2
Other Description BCL2-binding protein|apoptosis-stimulating of p53 protein 2|apoptosis-stimulating protein of p53, 2|renal carcinoma antigen NY-REN-51|tumor protein p53 binding protein, 2|tumor suppressor p53-binding protein 2
Swissprots Q96KQ3 Q86X75 Q13625 Q12892 B4DG66
Accessions EAW93247 EAW93248 Q13625 AA961496 AI042183 AJ318888 CAC83012 AK294432 BAG57677 AK294654 BAH11835 AK294964 BAG58037 AK295378 BAG58337 AK316016 BAH14387 AK316103 BAH14474 AL357233 BC040247 AAH40247 BC046150 AAH46150 BC058918 AAH58918 BX425756 U09582 AAA21597 U58334 AAC50557 XM_011544267 XP_011542569 XM_011544268 XP_011542570 XM_011544269 XP_011542571 XM_011544270 XP_011542572 NM_001031685 NP_001026855 NM_005426 NP_005417
Function Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}.
Subcellular Location Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42.
Tissue Specificity Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines. {ECO:0000269|PubMed:10498867, ECO:0000269|PubMed:10631318, ECO:0000269|PubMed:11684014}.
Top Pathways Hippo signaling pathway

53BP2 (H-4) - sc-398311 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
53BP2 (H-4): sc-398311. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic and nuclear localization.

53BP2 (DX54.10) - sc-53861 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
53BP2 (DX54.10): sc-53861. Western blot analysis of 53BP2 expression in WI 38 whole cell lysate.

53BP2 (19) - sc-135818 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
53BP2 (19): sc-135818. Immunofluorescence staining of human endothelial cells showing cytoplasmic staining.

53BP2 (N-15) - sc-10922 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
53BP2 (N-15): sc-10922. Western blot analysis of 53BP2 expression in Jurkat whole cell lysate.

53BP2 (H-60) - sc-367231 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

53BP2 (Q-15) - sc-10924 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

53BP2 (E-19) - sc-10920 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
53BP2 (E-19): sc-10920. Immunofluorescence staining of methanol-fixed Jurkat cells showing cytoplasmic localization.

Anti-53BP2/ASPP2 antibody - ab36004 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-53BP2/ASPP2 antibody (ab36004) at 1 µg/mlLane 1 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899)Lane 2 : MCF-7 (Human breast adenocarcinoma cell line) Whole Cell LysateLysates/proteins at 20 µg per lane.SecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-53BP2/ASPP2 antibody - ab70548 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-53BP2/ASPP2 antibody (ab70548) at 0.04 µg/mlLane 1 : Whole cell lysate from HeLa cells at 50 µgLane 2 : Whole cell lysate from HeLa cells at 15 µgLane 3 : Whole cell lysate from HeLa cells at 5 µgLane 4 : Whole cell lysate from 293T cells at 50 µgdeveloped using the ECL technique

Anti-53BP2/ASPP2 antibody - ab84996 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84996 at 1/500 dilution staining 53BP2/ASPP2 in human prostate adenocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

Anti-53BP2/ASPP2 antibody - ab129464 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-53BP2/ASPP2 antibody (ab129464) at 1/100 dilution + T47D cell lysate at 35 µgdeveloped using the ECL technique

Anti-53BP2/ASPP2 antibody [EPR13837] - ab181377 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13837
All lanes : Anti-53BP2/ASPP2 antibody [EPR13837] (ab181377) at 1/10000 dilutionLane 1 : Jurkat cell lysateLane 2 : Saos-2 cell lysateLane 3 : MCF7 cell lysateLysates/proteins at 10 µg per lane.

Anti-TP53BP2 / ASPP2 Antibody (aa825-875) - LS-C74335 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TP53BP2 / ASPP2 Antibody (aa425-475) - LS-C74334 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-TP53BP2 / ASPP2 Antibody (aa92-122, AP) - LS-C218074 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TP53BP2 / ASPP2 Antibody (aa92-122, APC) - LS-C218076 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TP53BP2 / ASPP2 Antibody (aa92-122, Biotin) - LS-C218075 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TP53BP2 / ASPP2 Antibody (aa92-122, FITC) - LS-C218077 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TP53BP2 / ASPP2 Antibody (aa92-122, PE) - LS-C218079 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TP53BP2 / ASPP2 Antibody (aa92-122, Azide-free, HRP) - LS-C218078 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TP53BP2 / ASPP2 Antibody (aa425-475) - LS-C286019 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TP53BP2 / ASPP2 Antibody (Internal) - LS-C59554 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ASPP2 Antibody - Western Blot. Western blot of Protein A purified anti-ASPP2 to detect over-expressed ASPP2 in MCF-7 cells (Lane 2, arrowhead). Lane 1 is a nontransfected control. Lane 3 is MCF-7 cells over-expressing ASPP1. Cell extracts were electrophoresed and transferred to nitrocellulose. The membrane was probed with the primary antibody at a 1:1000 dilution. The identity of the lower MW band at approximately 40kD is unknown. Personal Communication, H. Yang, Univ. Oklahoma, Oklahoma City, OK.

Anti-TP53BP2 / ASPP2 Antibody (aa92-122) - LS-C325877 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TP53BP2 / ASPP2 Antibody - LS-C341820 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TP53BP2 / ASPP2 Antibody (aa93-122) - LS-C160125 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TP53BP2 Antibody western blot of T47D cell line lysates (35 ug/lane). The TP53BP2 antibody detected the TP53BP2 protein (arrow).
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