| Gene Symbol |
Mcl1
|
| Entrez Gene |
60430
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
myeloid cell leukemia 1
|
| Other Description |
induced myeloid leukemia cell differentiation protein Mcl-1 homolog|myeloid cell leukemia sequence 1
|
| Swissprots |
Q9R289 Q9Z1P3 Q6AYY5
|
| Accessions |
EDL85696 Q9Z1P3 AF115380 AAD13295 AF144096 AAD31519 BC078835 AAH78835 NM_021846 NP_068618
|
| Function |
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
|
| Subcellular Location |
Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Cytoplasmic, associated with mitochondria.
|
| Tissue Specificity |
Ubiquitous. Highly expressed in heart, spleen, lung, liver, skeletal muscle and kidney. Detected at lower levels in brain, ovary, oviduct and testis. {ECO:0000269|PubMed:10579309}.
|
| Top Pathways |
PI3K-Akt signaling pathway, MicroRNAs in cancer
|