ADRA1B

Gene Symbol ADRA1B
Entrez Gene 147
Alt Symbol ADRA1, ALPHA1BAR
Species Human
Gene Type protein-coding
Description adrenoceptor alpha 1B
Other Description adrenergic, alpha-1B-, receptor|alpha-1B adrenergic receptor|alpha-1B adrenoceptor|alpha-1B adrenoreceptor|alpha-1B-adrenergic receptor
Swissprots B0LPE1 P35368
Accessions AAS21324 ABY87520 EAW61572 P35368 AK309989 BC136568 AAI36569 BC136569 AAI36570 BQ576306 BX648936 L31773 AAB59485 U03865 AAB60352 XM_005265818 XP_005265875 XM_005265819 XP_005265876 XM_006714821 XP_006714884 XM_011534435 XP_011532737 XM_011534436 XP_011532738 XM_011534437 XP_011532739 XM_011534438 XP_011532740 XM_011534439 XP_011532741 XM_011534440 XP_011532742 NM_000679 NP_000670
Function This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}.
Subcellular Location Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
Top Pathways Calcium signaling pathway, Vascular smooth muscle contraction, Salivary secretion, Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway

α 1B -AR (C-18) - sc-1476 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
α<sub>1B</sub>-AR (C-18): sc-1476. Western blot analysis of α<sub>1B</sub>-AR expression in rat heart tissue extract.

α 1B -AR (N-20) - sc-27136 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
α<sub>1B</sub>-AR (N-20): sc-27136. Western blot analysis of α<sub>1B</sub>-AR expression in SK-N-SH (A) and C2C12 (B) whole cell lysates.

α 1B -AR (G-16) - sc-26416 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-alpha 1b Adrenergic Receptor antibody - ab84405 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-alpha 1b Adrenergic Receptor antibody (ab84405) at 1/500 dilution + human fetal brain lysates

Anti-alpha 1b Adrenergic Receptor antibody - ab15851 from Abcam

Prices $372.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-alpha 1b Adrenergic Receptor antibody [EPR10336] - ab169523 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10336
All lanes : Anti-alpha 1b Adrenergic Receptor antibody [EPR10336] (ab169523) at 1/1000 dilutionLane 1 : Fetal brain lysateLane 2 : PC-3 lysateLane 3 : HeLa lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-ADRA1B Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A698 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ADRA1B antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-ADRA1B Antibody - LS-C125004 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-ADRA1B Antibody (aa431-480) - LS-C120552 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of LOVO cells, using ADRA1B Antibody. The picture on the right is treated with the synthesized peptide.

Anti-ADRA1B Antibody (aa388-437) - LS-C135678 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ADRA1B antibody LS-C135678 Western blot of THP-1 cell lysate.

Anti-ADRA1B Antibody (C-Terminus) IHC-plus™ - LS-A697 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ADRA1B antibody LS-A697 IHC of human adrenal, medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-ADRB1 Antibody - LS-C176870 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of AR-1 (A302) pAb in extracts from HT-29 cells.

Anti-ADRA1B Antibody (aa169-218) - LS-C135679 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ADRA1B antibody LS-C135679 Western blot of MCF7 cell lysate.

Anti-ADRA1B Antibody (aa380-409, AP) - LS-C250943 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADRA1B Antibody (aa266-278) - LS-C186439 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ADRA1B antibody (0.1 ug/ml) staining of Human Heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-ADRA1B Antibody - LS-C136928 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ADRA1B Antibody (aa380-409, APC) - LS-C250944 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADRA1B Antibody (aa380-409, Biotin) - LS-C250945 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADRA1B Antibody (aa380-409) - LS-C157538 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ADRA1B Antibody western blot of MDA-MB453 cell line lysates (35 ug/lane). The ADRA1B antibody detected the ADRA1B protein (arrow).

Anti-ADRA1B Antibody (aa252-264) - LS-C186438 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ADRA1B antibody (0.3 ug/ml) staining of Human Cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-ADRA1B Antibody (aa380-409, FITC) - LS-C250946 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADRA1B Antibody (aa380-409, PE) - LS-C250948 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADRA1B Antibody (aa276-306, AP) - LS-C250949 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADRA1B Antibody (aa380-409, Azide-free, HRP) - LS-C250947 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADRA1B Antibody (aa276-306, Azide-free, HRP) - LS-C250953 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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