| Gene Symbol |
ZNF746
|
| Entrez Gene |
155061
|
| Alt Symbol |
PARIS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger protein 746
|
| Other Description |
parkin interacting substrate|parkin-interacting substrate|parkin-interacting sustrate
|
| Swissprots |
Q6ZRF9 A8K6Z9 Q6NUN9
|
| Accessions |
EAW80042 EAW80043 Q6NUN9 AI991498 AK055975 BAB71061 AK128244 BAC87351 AK291814 BAF84503 BC031968 BC035586 BC068505 AAH68505 BM512385 XM_005249955 XP_005250012 XM_005249956 XP_005250013 XM_005249957 XP_005250014 XM_011515838 XP_011514140 NM_001163474 NP_001156946 NM_152557 NP_689770
|
| Function |
Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. {ECO:0000269|PubMed:21376232}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:21376232}. Nucleus {ECO:0000305|PubMed:21376232}. Note=Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes.
|
![Western Blot: ZNF746 Overexpression Lysate (Adult Normal) [NBP2-10209] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ZNF746.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7523_ZNF746%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10209-img0001.jpg)