| Gene Symbol |
Plscr3
|
| Entrez Gene |
360549
|
| Alt Symbol |
Pls3
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
phospholipid scramblase 3
|
| Other Description |
PL scramblase 3|ca(2+)-dependent phospholipid scramblase 3
|
| Swissprots |
Q6QBQ4 Q4V7A3
|
| Accessions |
Q6QBQ4 AY548831 AAS55061 BC098055 AAH98055 XM_008767838 XP_008766060 XM_008767839 XP_008766061 NM_001012139 NP_001012139
|
| Function |
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|