CYP2C8

Gene Symbol CYP2C8
Entrez Gene 1558
Alt Symbol CPC8, CYPIIC8, MP-12/MP-20
Species Human
Gene Type protein-coding
Description cytochrome P450, family 2, subfamily C, polypeptide 8
Other Description P450 form 1|cytochrome P450 2C8|cytochrome P450 IIC2|cytochrome P450 MP-12|cytochrome P450 MP-20|cytochrome P450 form 1|cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8|flavoprotein-linked monooxygenase|microsomal monooxygenase|s-mephenytoin 4-hydroxylase|xenobiotic monooxygenase
Swissprots P10632 B0AZN2 Q9UCZ9 Q8WWB1 A8K9N8 Q5VX93 B7Z1F6
Accessions AAR89907 CAA38578 EAW50016 EAW50017 EAW50018 P10632 AK292753 BAF85442 AK293327 BAH11491 AK293328 BAH11492 AK298401 BAH12777 AK303813 BAH14057 AK315823 BAF98714 BC020596 AAH20596 CD014119 DQ891400 ABM82326 DQ894579 ABM85505 M17397 AAA35739 M17398 AAA35740 M21941 AAA52160 M21942 AAA52161 X51535 CAA35915 Y00498 CAA68550 XR_945610 NM_000770 NP_000761 NM_001198853 NP_001185782 NM_001198854 NP_001185783 NM_001198855 NP_001185784 NM_030878
Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti- cancer drug paclitaxel (taxol). {ECO:0000269|PubMed:7574697}.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Top Pathways Chemical carcinogenesis, Arachidonic acid metabolism, Linoleic acid metabolism, Retinol metabolism, Drug metabolism - cytochrome P450

CYP2C8 (E-13) - sc-164136 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CYP2C8 antibody - ab126844 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-CYP2C8 antibody (ab126844) at 0.1 µg/ml + Human Liver lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-CYP2C8 antibody - ab88904 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-CYP2C8 antibody (ab88904) at 1/500 dilution + human liver tissue lysate at 50 µg

Anti-CYP2C8 antibody - ab103547 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CYP2C8 antibody (ab103547) at 1/500 dilution + Human liver tissue lysate at 50 µg

Anti-CYP2C8 Antibody - LS-C311070 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYP2C8 Antibody (Internal) - LS-C154876 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal
CYP2C8 antibody (0.1 ug/ml) staining of Human Liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-CYP2C8 Antibody (N-Terminus) - LS-C99806 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of anti-CYP2C8 Antibody in T47D cell line lysates (35 ug/lane). CYP2C8(arrow) was detected using the purified antibody.

Anti-CYP2C8 Antibody - LS-C6343 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYP2C8 Antibody - LS-C6344 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYP2C8 Antibody (aa241-290) - LS-C119496 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYP2C8 Antibody (aa1-490) - LS-C128491 from LifeSpan Bioscience

Host Mouse
Clonality Polyclonal

Cytochrome P450 2C8 Antibody - NBP2-16078 from Novus Biologicals

Prices $89.00, $329.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Cytochrome P450 2C8 Antibody [NBP2-16078] - Sample (30 ug of whole cell lysate) A: HeLa B: HepG2 7. 5% SDS PAGE gel, diluted at 1:5000.

Cytochrome P450 2C8/9/18/19 Antibody - NB100-92425 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Cytochrome P450 2C8/9/18/19 Antibody [NB100-92425] - Extracts from LOVO cells.

Cytochrome P450 2C8 Antibody - NBP1-88054 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Cytochrome P450 2C8 Antibody [NBP1-88054] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human plasma (IgG/HSA depleted). Lane 5: Human liver tissue. Lane 6: Human tonsil tissue

Cytochrome P450 2C8 Antibody - H00001558-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Cytochrome P450 2C8 Antibody [H00001558-D01P] - CYP2C8 MaxPab rabbit polyclonal antibody. Western Blot analysis of CYP2C8 expression in human liver.

Cytochrome P450 2C8 Antibody - NBP1-88055 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Cytochrome P450 2C8 Antibody [NBP1-88055] - Staining of human liver shows strong cytoplasmic positivity in hepatocytes.

Cytochrome P450 2C8 Antibody - NBP1-97759 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: Cytochrome P450 2C8 Antibody [NBP1-97759] - (0.1ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Cytochrome P450 2C8 Antibody - H00001558-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: Cytochrome P450 2C8 Antibody [H00001558-B01P] - Analysis of CYP2C8 expression in human liver.

Anti-CYP2C8 antibody produced in rabbit - HPA013547 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CYP2C8: <B>Cat. No. HPA013547</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human liver shows strong nuclear and cytoplasmic positivity in hepatocytes.

Anti-CYP2C8 antibody produced in rabbit - SAB1410276 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CYP2C8: <B>Cat. No. SAB1410276</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~55.8 kDa using human liver lysate.

Anti-CYP2C8 antibody produced in goat - SAB2501735 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CYP2C8: <B>Cat. No. SAB2501735</B>: (0.1 μg/mL) staining of Human Liver lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-CYP2C8 antibody produced in rabbit - HPA013970 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CYP2C8: <B>Cat. No. HPA013970</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human liver shows strong cytoplasmic positivity in hepatocytes.

CYP2C8 Antibody - C-terminal region (ARP60128_P050) - ARP60128_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CP2C8 Antibody - N-terminal region (ARP60129_P050) - ARP60129_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CYP2C8-Antibody-N-term - AP7995a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of anti-CYP2C8 Antibody (N-term) (Cat.#AP7995a) in T47D cell line lysates (35ug/lane). CYP2C8(arrow) was detected using the purified Pab.
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