Trp53bp2

Gene Symbol Trp53bp2
Entrez Gene 209456
Alt Symbol 53BP2, AI746547, ASPP2, PPP1R13A, Tp53bp2, X98550
Species Mouse
Gene Type protein-coding
Description transformation related protein 53 binding protein 2
Other Description apoptosis-stimulating of p53 protein 2|p53-binding protein 2|p53BP2|tumor protein p53 binding protein, 2|tumor suppressor p53-binding protein 2
Swissprots Q8K2L5 Q3UYM7 Q8CG79
Accessions EDL13107 Q8CG79 AK133930 BAE21932 AK134556 BAE22185 AK189404 AK195318 AW990556 BC025187 BC030894 AAH30894 BC042874 BQ180182 BY020445 CN529251 NM_173378 NP_775554
Function Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates p53/TP53 by enhancing the DNA binding and transactivation function of p53/TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42 (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. {ECO:0000250}.
Top Pathways Hippo signaling pathway

53BP2 CRISPR/Cas9 KO Plasmid (m) - sc-431638 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

53BP2 HDR Plasmid (m) - sc-431638-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

53BP2 Double Nickase Plasmid (m) - sc-431638-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

53BP2 Double Nickase Plasmid (m2) - sc-431638-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

53BP2 CRISPR Activation Plasmid (m) - sc-431638-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

53BP2 CRISPR Activation Plasmid (m2) - sc-431638-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

53BP2 Lentiviral Activation Particles (m) - sc-431638-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

53BP2 Lentiviral Activation Particles (m2) - sc-431638-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

53BP2 siRNA (m) - sc-37458 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

53BP2 shRNA Plasmid (m) - sc-37458-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

53BP2 shRNA (m) Lentiviral Particles - sc-37458-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU084621 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN43516 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND43516 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

TP53BP2 siRNA (Mouse) - CRN1643 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

TP53BP2 - MBS8228993 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse Trp53bp2 (NM_173378.2) - SHH435480 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse TP53BP2 siRNA - orb291118 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

TP53BP2 shRNA Plasmid (Mouse) - CHN1643 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

TRP53BP2 miRNA 3'UTR clone - MiUTR1M-12174 from Creative biogene

Species Reactivities Mouse
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