CHUK

Gene Symbol	CHUK
Entrez Gene	1147
Alt Symbol	IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16
Species	Human
Gene Type	protein-coding
Description	conserved helix-loop-helix ubiquitous kinase
Other Description	I-kappa-B kinase 1|I-kappa-B kinase-alpha|IKK-a kinase|IkB kinase alpha subunit|Nuclear factor NFkappaB inhibitor kinase alpha|TCF-16|inhibitor of nuclear factor kappa-B kinase subunit alpha|transcription factor 16
Swissprots	Q5W0I4 O14666 O15111 Q92467 Q13132
Accessions	AAT49098 EAW49845 O15111 AB209028 BAD92265 AF009225 AAC51671 AF012890 AAC51662 AF080157 AAD08996 AL133012 AL521750 BC034796 BC092514 AAH92514 BM800404 U22512 AAC50713 XM_011539196 XP_011537498 XM_011539197 XP_011537499 XM_011539198 XP_011537500 XR_945589 XR_945590 NM_001278 NP_001269
Function	Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12789342}. Nucleus {ECO:0000269|PubMed:12789342}. Note=Shuttles between the cytoplasm and the nucleus.
Tissue Specificity	Widely expressed.
Top Pathways	Measles, Toll-like receptor signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, Herpes simplex infection, Adipocytokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® IKKα siRNA I - 6372 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® IKKα siRNA II - 6373 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

IKKα CRISPR/Cas9 KO Plasmid (h) - sc-400492 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IKKα HDR Plasmid (h) - sc-400492-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IKKα Double Nickase Plasmid (h) - sc-400492-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IKKα Double Nickase Plasmid (h2) - sc-400492-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IKKα CRISPR Activation Plasmid (h) - sc-400492-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IKKα CRISPR Activation Plasmid (h2) - sc-400492-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IKKα Lentiviral Activation Particles (h) - sc-400492-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IKKα Lentiviral Activation Particles (h2) - sc-400492-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IKKα siRNA (h) - sc-29365 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IKKα shRNA Plasmid (h) - sc-29365-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IKKα shRNA (h) Lentiviral Particles - sc-29365-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IKK alpha RNAi - H00001147-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU229471 from Sigma-Aldrich Category siRNA Prices $140.00, $140.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0423 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0424 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0422 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1521 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1521 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CHUK siRNA (Human) - CRH0824 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CHUK - MBS8235494 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

IKKα CRISPR/Cas9 KO Plasmid (h2) - sc-400492-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IKKα HDR Plasmid (h2) - sc-400492-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human CHUK (NM_001278.3) - SHH263929 from Creative biogene Category siRNA Species Reactivities Human

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