| Gene Symbol |
Gapdh
|
| Entrez Gene |
14433
|
| Alt Symbol |
Gapd
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
glyceraldehyde-3-phosphate dehydrogenase
|
| Other Description |
peptidyl-cysteine S-nitrosylase GAPDH
|
| Swissprots |
P16858 Q0QEU0 Q4V783 Q3THM2 Q3TUI2 Q5U410 Q3UMT2 Q569X5 A6H6A8 Q569X2
|
| Accessions |
EDK99813 P16858 AK002273 BAB21979 AK081405 BAC38211 AK140794 BAE24481 AK144690 BAE26016 AK146435 BAE27169 AK147738 BAE28105 AK147891 BAE28208 AK160399 BAE35768 AK160753 BAE35989 AK164415 BAE37778 AK168217 BAE40174 AK169742 AK178056 AK178680 AK179849 AK184044 AK184442 AK184664 AK184690 AK185135 AK186650 AK189223 AK190093 AK190100 AK190330 AK190481 AK190634 AK190771 AK190937 AK191255 AK191361 AK191558 AK191930 AK191938 AK192040 AK192123 AK192402 AK192522 AK192930 AK193656 AK193664 AK194000 AK194274 AK194309 AK194315 AK194885 AK195420 AK195667 AK195724 AK196170 AK196250 AK196299 AK196324 AK196391 AK196504 AK196631 AK197155 AK197268 AK197552 AK197791 AK197873 AK198019 AK198344 AK198590 AK198622 AK198692 AK199039 AK199353 AK199531 AK199549 AK199608 AK199860 AK200221 AK200222 AK200475 AK200636 AK201249 AK201401 AK201453 AK201486 AK201736 AK201876 AK202784 AK203035 AK203145 AK203274 AK203291 AK203511 AK203514 AK203950 AK204125 AK204182 AK204204 AK204369 AK204431 AK204435 AK204477 AK204478 AK204659 AK205615 AK206172 AK211452 AK213421 AK214525 AK218066 AK218240 AK218826 AY618199 AAU89484 BC020407 BC023196 BC082592 AAH82592 BC083065 AAH83065 BC083079 AAH83079 BC083080 AAH83080 BC083149 AAH83149 BC085274 AAH85274 BC085275 AAH85275 BC085315 AAH85315 BC091736 BC091768 AAH91768 BC092252 AAH92252 BC092264 AAH92264 BC092267 AAH92267 BC092294 AAH92294 BC093508 AAH93508 BC094037 AAH94037 BC095932 AAH95932 BC096042 AAH96042 BC096440 AAH96440 BC096590 AAH96590 BC110311 AAI10312 BC145810 AAI45811 BC145812 AAI45813 BI851476 BU504528 CJ155387 DQ403054 ABD77187 GU214026 ADA57700 KF982306 AHL58824 M32599 AAA37659 XM_011241212 XP_011239514 XM_011241213 XP_011239515 XM_011241214 XP_011239516 NM_001289726 NP_001276655 NM_008084 NP_032110
|
| Function |
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3- phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S- nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in infl
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal. {ECO:0000250}.
|
| Top Pathways |
Glycolysis / Gluconeogenesis, Alzheimer's disease, Biosynthesis of amino acids, Carbon metabolism
|