| Gene Symbol | ITGAL |
|---|---|
| Entrez Gene | 3683 |
| Alt Symbol | CD11A, LFA-1, LFA1A |
| Species | Human |
| Gene Type | protein-coding |
| Description | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) |
| Other Description | CD11 antigen-like family member A|LFA-1 alpha|LFA-1A|antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide|integrin alpha-L|integrin gene promoter|leukocyte adhesion glycoprotein LFA-1 alpha chain|leukocyte function-associated molecule 1 alpha chain|lymphocyte function-associated antigen 1 |
| Swissprots | Q9UBC8 O43746 Q96HB1 Q45H73 P20701 |
| Accessions | AAA16474 AAC31672 AAZ38713 CAA80461 EAW52243 EAW52244 EAW52245 P20701 AK298674 BAG60839 AK303190 BAG64283 AK314246 BAG36913 BC008777 AAH08777 CA430398 DC324373 Y00796 CAA68747 XM_005255313 XP_005255370 XM_006721044 XP_006721107 XM_011545849 XP_011544151 XR_950794 NM_001114380 NP_001107852 NM_002209 NP_002200 |
| Function | Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Leukocytes. |
| Top Pathways | Malaria, Rap1 signaling pathway, Epstein-Barr virus infection, HTLV-I infection, Rheumatoid arthritis |