MARK2

Gene Symbol MARK2
Entrez Gene 2011
Alt Symbol EMK-1, EMK1, PAR-1, Par-1b, Par1b
Species Human
Gene Type protein-coding
Description MAP/microtubule affinity-regulating kinase 2
Other Description ELKL motif kinase 1|PAR1 homolog b|Ser/Thr protein kinase PAR-1B|serine/threonine protein kinase EMK|serine/threonine-protein kinase MARK2
Swissprots Q7KZI7 Q5XGA3 Q15524 Q96RG0 Q15449 Q68A18 Q96HB3
Accessions EAW74174 EAW74175 EAW74176 EAW74177 EAW74178 EAW74179 EAW74180 Q7KZI7 AB188493 BAD37141 AB271694 BAF96440 AF387638 AAK82368 AI524222 AK225766 AK290339 BAF83028 AK307858 AY562187 AAT67601 AY562188 AAT67602 BC008771 AAH08771 BC084540 AAH84540 BM719402 BM724555 BT007342 AAP36006 BX383836 DA855402 DQ578603 DQ890693 ABM81619 DQ893876 ABM84802 X97630 CAA66229 Z25427 CAA80914 XM_011544789 XP_011543091 XM_011544790 XP_011543092 XM_011544791 XP_011543093 XM_011544792 XP_011543094 XM_011544793 XP_011543095 XM_011544794 XP_011543096 XM_011544795 XP_011543097 XM_011544796 XP_011543098 XM_011544797 XP_011543099 XM_011544798 XP_011543100 XR_949801 XR_949802 NM_001039469 NP_001034558 NM_001163296 NP_001156768 NM_001163297 NP_001156769 NM_004954 NP_004945 NM_017490 NP_059672
Function Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule- dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDA
Subcellular Location Cell membrane; Peripheral membrane protein. Cytoplasm. Lateral cell membrane. Cytoplasm, cytoskeleton. Note=Phosphorylation at Thr-596 by PRKCZ/aPKC and subsequent interaction with 14-3-3 protein YWHAZ promotes relocation from the cell membrane to the cytoplasm.
Tissue Specificity High levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney. {ECO:0000269|PubMed:9730619}.

MARK2 Antibody - 9118 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using MARK2 Antibody.

MARK2 (B-1) - sc-365405 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MARK2 (B-1): sc-365405. Western blot analysis of MARK2 expression in H4 whole cell lysate.

MARK2 (C-16) - sc-46607 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MARK2 (C-16): sc-46607. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic and membrane staining of myocytes.

MARK2 (H-86) - sc-98800 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MARK2 (H-86): sc-98800. Western blot analysis of MARK2 expression in non-transfected: sc-110760 (A) and human MARK2 transfected: sc-172541 (B) 293 whole cell lysates.

Anti-MARK 1+2+3+4 (phospho T215) antibody - ab111437 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111437, at 1/50 dilution, staining MARK 1+2+3+4 in paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry, in the presence (right panel) or absence (left panel) of immunising peptide.

Anti-MARK 1+2+3+4 antibody - ab74131 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MARK 1+2+3+4 antibody (ab74131) at 1/500 dilutionLane 1 : Extracts from COS-7 cellsLane 2 : Extracts from COS-7 cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-MARK2 antibody - ab133178 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human heart tissue labelling MARK2 with ab133178 antibody at a concentration of 10 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-MARK2 antibody - ab54997 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab54997 MARK2 antibody at 1ug/ml.

Anti-MARK2 antibody [EPR8553] - ab133724 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8553
All lanes : Anti-MARK2 antibody [EPR8553] (ab133724) at 1/1000 dilutionLane 1 : RAW 264.7 cell lysateLane 2 : NIH/3T3 cell lysateLane 3 : Neuro-2a cell lysateLane 4 : Jurkat cell lysateLane 5 : Raji cell lysateLane 6 : U-87 MG cell lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP labelled goat anti-rabbit at 1/2000 dilutiondeveloped using the ECL technique

Anti-MARK2 antibody - C-terminal - ab135816 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MARK2 antibody - C-terminal (ab135816) at 1/250 dilution + mouse thymus tissue lysates at 35 µg

Anti-MARK2 antibody - N-terminal - ab136872 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human kidney tubules labelling ab136872 at 10µg/ml.

Anti-MARK2 Antibody - LS-C334384 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of Mouse brain cell lines, using MARK2 antibody.

Anti-MARK2 Antibody (aa500-510) - LS-C61766 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.3 ug/ml) staining of Human Brain (Cerebellum) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-MARK2 Antibody (aa10-59) IHC-plus™ - LS-B7503 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-MARK2 antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7503 concentration 10 ug/ml.

Anti-MARK2 Antibody (C-Terminus, clone EPR8553) - LS-C154646 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8553
Western blot analysis on (A) Raw 264.7, (B) NIH/3T3, (C) Neuro-2a, (D) Jurkat, (E) Raji, and (F) U87-MG cell lysates using anti-MARK2 antibody.

Anti-MARK2 Antibody (clone 3B12) - LS-C197132 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3B12
MARK2 monoclonal antibody (M01), clone 3B12. Western Blot analysis of MARK2 expression in NIH/3T3.

Anti-MARK2 Antibody (aa600-630) - LS-C99815 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-MARK2 Antibody (phospho-Thr595) - LS-C18889 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MARK2 Antibody (aa1-755) - LS-C130658 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PAR-1 / MARK2 Antibody (aa639-652) - LS-C148036 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-MARK2 Antibody (C-Terminus, AP) - LS-C279249 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MARK2 Antibody (C-Terminus, APC) - LS-C279251 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MARK2 Antibody (C-Terminus, Biotin) - LS-C279253 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MARK2 Antibody (C-Terminus, FITC) - LS-C279254 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MARK2 Antibody (C-Terminus, Azide-free, HRP) - LS-C279255 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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