SCARB1
| Gene Symbol | SCARB1 |
|---|---|
| Entrez Gene | 949 |
| Alt Symbol | CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | scavenger receptor class B, member 1 |
| Other Description | CD36 and LIMPII analogous 1|CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1|scavenger receptor class B member 1|scavenger receptor class B type III |
| Swissprots | Q14016 F8W8N0 Q52LZ5 Q8WTV0 Q6KFX4 |
| Accessions | EAW98458 EAW98459 EAW98460 EAW98461 EAW98462 Q8WTV0 AB209436 BAD92673 AF254409 AAF91347 AF515445 AAQ08185 AK124112 BAG54008 AK302779 BAG63983 AK304730 BAG65493 BC022087 BC034322 BC080647 AAH80647 BC093732 AAH93732 BC112037 AAI12038 BC143319 AAI43320 BG770204 CA428516 DQ892837 ABM83763 DQ896083 ABM87082 Z22555 CAA80277 NM_001082959 NP_001076428 NM_005505 NP_005496 |
| Function | Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae. |
| Tissue Specificity | Widely expressed. |
| Top Pathways | Phagosome, Hepatitis C, Bile secretion, Fat digestion and absorption, Vitamin digestion and absorption |
SR-B1 CRISPR/Cas9 KO Plasmid (h) - sc-400990 from Santa Cruz Biotechnology
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SR-B1 HDR Plasmid (h) - sc-400990-HDR from Santa Cruz Biotechnology
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SR-B1 Double Nickase Plasmid (h) - sc-400990-NIC from Santa Cruz Biotechnology
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SR-B1 Double Nickase Plasmid (h2) - sc-400990-NIC-2 from Santa Cruz Biotechnology
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SR-B1 CRISPR Activation Plasmid (h) - sc-400990-ACT from Santa Cruz Biotechnology
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SR-B1 CRISPR Activation Plasmid (h2) - sc-400990-ACT-2 from Santa Cruz Biotechnology
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SR-B1 Lentiviral Activation Particles (h) - sc-400990-LAC from Santa Cruz Biotechnology
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SR-B1 Lentiviral Activation Particles (h2) - sc-400990-LAC-2 from Santa Cruz Biotechnology
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SR-B1 siRNA (h) - sc-44752 from Santa Cruz Biotechnology
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SR-B1 shRNA Plasmid (h) - sc-44752-SH from Santa Cruz Biotechnology
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SR-B1 shRNA (h) Lentiviral Particles - sc-44752-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU125211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18893 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18893 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07403 from Sigma-Aldrich
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SCARB1 siRNA (Human) - CRH0671 from Cohesion Biosciences
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SR-BI RNAi - H00000949-R01 from Novus Biologicals
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SCARB1 - MBS8210103 from MyBioSource
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shRNA set against Human SCARB1 (NM_005505.4) - SHH402408 from Creative biogene
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shRNA set against Human SCARB1(NM_001082959.1) - SHR206960 from Creative biogene
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shRNA set against Human SCARB1(NM_005505.4) - SHR207040 from Creative biogene
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shRNA set against Human SCARB1(NM_001082959.1) - SHR207076 from Creative biogene
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SCARB1 shRNA Plasmid (Human) - CHH0671 from Cohesion Biosciences
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SCARB1 miRNA 3'UTR clone - MiUTR1H-09156 from Creative biogene
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SCARB1 miRNA 3'UTR clone - MiUTR1H-09157 from Creative biogene
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