| Gene Symbol | ATP1A3 |
|---|---|
| Entrez Gene | 478 |
| Alt Symbol | AHC2, CAPOS, DYT12, RDP |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATPase, Na+/K+ transporting, alpha 3 polypeptide |
| Other Description | Na(+)/K(+) ATPase alpha(III) subunit|Na(+)/K(+) ATPase alpha-3 subunit|Na+/K+ ATPase 3|sodium pump subunit alpha-3|sodium-potassium ATPase catalytic subunit alpha-3|sodium-potassium-ATPase, alpha 3 polypeptide|sodium/potassium-transporting ATPase alpha-3 chain|sodium/potassium-transporting ATPase subunit alpha-3 |
| Swissprots | B7Z2T0 F5H6J6 B7Z401 Q969K5 P13637 Q16735 |
| Accessions | AAA51798 AAA52285 AAA52286 AAA53499 AAA58380 CAA31390 EAW57089 P13637 AK054736 BAG51420 AK094628 BAG52899 AK122693 BAG53671 AK223569 BAD97289 AK293784 BAH11595 AK295078 BAH11966 AK295833 BAH12194 AK296557 BAH12387 AK307921 AK316069 BAH14440 AL832884 AY946015 AAX55910 BC009282 AAH09282 BC009394 AAH09394 BC013763 BC015566 AAH15566 BX478337 CB156520 DB482528 JF432325 ADZ15542 XM_011526991 XP_011525293 NM_001256213 NP_001243142 NM_001256214 NP_001243143 NM_152296 NP_689509 |
| Function | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:7711835}; Multi-pass membrane protein {ECO:0000269|PubMed:7711835}. |
| Top Pathways | Salivary secretion, Cardiac muscle contraction, cAMP signaling pathway, Aldosterone-regulated sodium reabsorption, Thyroid hormone synthesis |
Na + /K + -ATPase α3 CRISPR/Cas9 KO Plasmid (h) - sc-416366 from Santa Cruz Biotechnology
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Na + /K + -ATPase α3 HDR Plasmid (h) - sc-416366-HDR from Santa Cruz Biotechnology
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Na + /K + -ATPase α3 Double Nickase Plasmid (h) - sc-416366-NIC from Santa Cruz Biotechnology
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Na + /K + -ATPase α3 Double Nickase Plasmid (h2) - sc-416366-NIC-2 from Santa Cruz Biotechnology
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Na + /K + -ATPase α3 CRISPR Activation Plasmid (h) - sc-416366-ACT from Santa Cruz Biotechnology
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Na + /K + -ATPase α3 CRISPR Activation Plasmid (h2) - sc-416366-ACT-2 from Santa Cruz Biotechnology
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Na + /K + -ATPase α3 Lentiviral Activation Particles (h) - sc-416366-LAC from Santa Cruz Biotechnology
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Na + /K + -ATPase α3 Lentiviral Activation Particles (h2) - sc-416366-LAC-2 from Santa Cruz Biotechnology
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Na + /K + -ATPase α3 siRNA (h) - sc-36012 from Santa Cruz Biotechnology
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Na + /K + -ATPase α3 shRNA Plasmid (h) - sc-36012-SH from Santa Cruz Biotechnology
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Na + /K + -ATPase α3 shRNA (h) Lentiviral Particles - sc-36012-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU119991 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3681 from Sigma-Aldrich
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ATP1A3 siRNA (Human) - CRH0334 from Cohesion Biosciences
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Sodium Potassium ATPase Alpha 3 RNAi - H00000478-R02 from Novus Biologicals
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ATP1A3 - MBS8210120 from MyBioSource
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shRNA set against Human Atp1a3 (NM_152296.4) - SHH242530 from Creative biogene
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Human ATP1A3 siRNA - orb260836 from Biorbyt
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ATP1A3 shRNA Plasmid (Human) - CHH0334 from Cohesion Biosciences
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ATP1A3 miRNA 3'UTR clone - MiUTR3H-02115 from Creative biogene
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