Aph1a

Gene Symbol Aph1a
Entrez Gene 226548
Alt Symbol 6530402N02Rik, APH-1a
Species Mouse
Gene Type protein-coding
Description anterior pharynx defective 1a homolog (C. elegans)
Other Description aph-1alpha|gamma-secretase subunit APH-1A
Swissprots Q8BVF7 Q8R1T3 Q91VL5
Accessions EDL38851 EDL38853 Q8BVF7 AK050828 AK078343 BAC37228 AK148400 BAE28531 AK152334 BAE31132 AK177784 AK178736 AK181631 AK181860 AK182589 AK189692 AK189810 AK190617 AK190873 AK195745 AK197207 AK197636 AK197667 AK202378 AK204454 AK206190 AK213745 AK215415 AK216088 AK217389 AK218564 AX775953 CAE11676 BC012406 AAH12406 BC024111 AAH24111 BC057865 AAH57865 BY264531 CX207467 XM_006501312 XP_006501375 NM_146104 NP_666216 NM_146134 NP_666246
Function Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). {ECO:0000250}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi. {ECO:0000250}.
Top Pathways Notch signaling pathway, Alzheimer's disease

Aph-1 CRISPR/Cas9 KO Plasmid (m) - sc-432640 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Aph-1 HDR Plasmid (m) - sc-432640-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Aph-1 Double Nickase Plasmid (m) - sc-432640-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Aph-1 Double Nickase Plasmid (m2) - sc-432640-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Aph-1 CRISPR Activation Plasmid (m) - sc-432640-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Aph-1 CRISPR Activation Plasmid (m2) - sc-432640-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Aph-1 Lentiviral Activation Particles (m) - sc-432640-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Aph-1 Lentiviral Activation Particles (m2) - sc-432640-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Aph-1 siRNA (m) - sc-141150 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Aph-1 shRNA Plasmid (m) - sc-141150-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Aph-1 shRNA (m) Lentiviral Particles - sc-141150-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU091711 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN26824 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND26824 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

APH1A siRNA (Mouse) - CRN2525 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

APH1A - MBS8222904 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse APH1A (NM_146104.2) - SHH238202 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Aph1a(NM_146104.2) - SHG064639 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse APH1A siRNA - orb292000 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

APH1A shRNA Plasmid (Mouse) - CHN2525 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

APH1A miRNA 3'UTR clone - MiUTR1M-01569 from Creative biogene

Species Reactivities Mouse
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