GPS1

Gene Symbol GPS1
Entrez Gene 2873
Alt Symbol COPS1, CSN1
Species Human
Gene Type protein-coding
Description G protein pathway suppressor 1
Other Description COP9 signalosome complex subunit 1|COP9 signalosome subunit 1|GPS-1|JAB1-containing signalosome subunit 1|SGN1|signalosome subunit 1
Swissprots Q8NA10 Q9BWL1 Q13098
Accessions EAW89741 EAW89742 Q13098 AB209596 BAD92833 AK026610 AK093283 BAC04120 AK222508 AK225248 AK289435 BAF82124 AK297872 BAG60198 BC000155 AAH00155 BC064503 AAH64503 BG775520 BT009834 AAP88836 EU832312 ACE87569 EU832397 ACE86882 HQ258557 ADR83311 U20285 AAC50906 XM_005256350 XP_005256407 XM_005256351 XP_005256408 XM_005256353 XP_005256410 XM_005256354 XP_005256411 XM_005256357 XP_005256414 XM_005256358 XP_005256415 XM_005256359 XP_005256416 XM_005256360 XP_005256417 XM_005256362 XP_005256419 XM_005256363 XP_005256420 XM_011523563 XP_011521865 XM_011523564 XP_011521866 XM_011523565 XP_011521867 XM_011523566 XP_011521868 XM_011523567 XP_011521869 XM_011523568 XP_011521870 XM_011523569 XP_011521871 XM_011523570 XP_011521872 NM_004127 NP_004118 NM_212492 NP_997657
Function Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:8943324}.

CSN1 (F-8) - sc-377134 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CSN1 (F-8): sc-377134. Western blot analysis of CSN1 expression in HeLa (A) and HEL 92.1.7 (B) whole cell lysates.

CSN1 (E-4) - sc-514086 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CSN1 (E-4): sc-514086. Western blot analysis of CSN1 expression in non-transfected: sc-117752 (A) and mouse CSN1 transfected: sc-125175 (B) 293T whole cell lysates.

CSN1 (C-19) - sc-47853 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CSN1 (C-19): sc-47853. Western blot analysis of CSN1 expression in non-transfected: sc-110760 (A) and human CSN1 transfected: sc-110484 (B) 293 whole cell lysates.

CSN1 (H-233) - sc-135210 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CSN1 (H-233): sc-135210. Western blot analysis of CSN1 expression in non-transfected: sc-117752 (A) and mouse CSN1 transfected: sc-125175 (B) 293T whole cell lysates.

CSN1 (K-19) - sc-47854 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CSN1 (K-19): sc-47854. Western blot analysis of CSN1 expression in non-transfected: sc-110760 (A) and human CSN1 transfected: sc-110484 (B) 293 whole cell lysates.

CSN1 (H-41) - sc-292637 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CSN1 (H-41): sc-292637. Western blot analysis of CSN1 expression in non-transfected 293T: sc-117752 (A), mouse CSN1 transfected 293T: sc-125175 (B) and HEL 92.1.7 (C) whole cell lysates.

CSN1 (N-13) - sc-47855 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CSN1 (N-13): sc-47855. Western blot analysis of CSN1 expression in HeLa (A), HEL 92.1.7 (B) and NIH/3T3 (C) whole cell lysates.

CSN1 (N-18) - sc-47856 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CSN1 (N-18): sc-47856. Western blot analysis of CSN1 expression in HEL 92.1.7 (A) and HL-60 (B) whole cell lysates.

CSN1 (D-4) - sc-365617 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CSN1 (D-4): sc-365617. Western blot analysis of CSN1 expression in HEL 92.1.7 (A) and HeLa (B) whole cell lysates.

Anti-CSN1 (phospho S474) antibody - ab111894 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111894 at 1/50 dilution staining CSN1 in paraffin-embedded Human Brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

Anti-CSN1 antibody - ab169313 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Anti-CSN1 antibody (ab169313) at 1/500 dilution + Human spleen lysate at 50 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-CSN1 antibody - ab10413 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma tissue labelling CSN1 with ab10413 at 1/1000 (1µg/ml). Detection: DAB.

Anti-CSN1 antibody - ab4535 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-CSN1 antibody - ab84411 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human prostate nodular hypertrophy, using 1/250 ab84411 followed by DAB staining.

Anti-CSN1 antibody [EP15642-22] - ab194359 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP15642-22
All lanes : Anti-CSN1 antibody [EP15642-22] (ab194359) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : K562 cell lysateLane 3 : MCF7 cell lysateLane 4 : 293T cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Anti-CSN1 antibody [EPR15642] - ab187658 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EPR15642
All lanes : Anti-CSN1 antibody [EPR15642] (ab187658) at 1/10000 dilutionLane 1 : K562 cell lysateLane 2 : HeLa cell lysateLane 3 : MCF7 cell lysateLane 4 : 293T cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-GPS1 / CSN1 Antibody - LS-C63925 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GPS1 / CSN1 Antibody (aa141-170, Biotin) - LS-C214920 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GPS1 / CSN1 Antibody (aa141-170, AP) - LS-C214915 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GPS1 / CSN1 Antibody (aa141-170, APC) - LS-C214918 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GPS1 / CSN1 Antibody (aa141-170, FITC) - LS-C214919 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GPS1 / CSN1 Antibody (aa141-170, Azide-free, HRP) - LS-C214921 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GPS1 / CSN1 Antibody (aa141-170, PE) - LS-C214922 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GPS1 / CSN1 Antibody (aa82-131) - LS-C151342 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GPS1 / CSN1 antibody Western Blot of HT1080.

Anti-GPS1 / CSN1 Antibody (aa184-214) - LS-C321770 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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