TH

Gene Symbol TH
Entrez Gene 7054
Alt Symbol DYT14, DYT5b, TYH
Species Human
Gene Type protein-coding
Description tyrosine hydroxylase
Other Description dystonia 14|tyrosine 3-hydroxylase|tyrosine 3-monooxygenase
Swissprots Q2M3B4 B7ZL70 B7ZL73 P07101 Q0PWM2 Q15585 Q15588 Q0PWM3 Q15589
Accessions AAA61170 AAA61171 AAA61172 AAA61173 AAA77650 AAA77651 AAN73289 AAN73290 AAP43671 BAA25094 BAA25095 BAA25096 BAA25097 EAX02490 EAX02491 EAX02492 EAX02493 EAX02494 P07101 AA447751 AY144494 AAN39538 AY144495 AAN39539 BC104967 AAI04968 BC143611 AAI43612 BC143614 AAI43615 BM718799 DQ677336 ABG73364 DQ677337 ABG73365 M17589 AAA61179 M20911 AAA61167 M20912 AAA61168 M24790 AAA61174 X05290 CAA28908 Y00414 CAA68472 XM_011520335 XP_011518637 NM_000360 NP_000351 NM_199292 NP_954986 NM_199293 NP_954987
Function Plays an important role in the physiology of adrenergic neurons.
Tissue Specificity Mainly expressed in the brain and adrenal glands.
Top Pathways Dopaminergic synapse, Amphetamine addiction, Cocaine addiction, Alcoholism, Prolactin signaling pathway

Phospho-Tyrosine Hydroxylase (Ser40) Antibody - 2791 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from PC12 cells, untreated or forskolin-treated (30 µM), using Phospho-Tyrosine Hydroxylase (Ser40) Antibody (upper) or Tyrosine Hydroxylase Antibody #2792 (lower).

Tyrosine Hydroxylase Antibody - 2792 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from SK-N-MC (human), SH-SY5Y (human) and PC12 (rat) cells as well as rat cerebrum and mouse whole brain tissue, using Tyrosine Hydroxylase Antibody.

TH (A-1) - sc-374047 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TH (A-1): sc-374047. Western blot analysis of TH expression in PC-12 whole cell lysate.

TH (A-6) - sc-374048 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TH (A-6): sc-374048. Western blot analysis of TH expression in PC-12 whole cell lysate.

TH (C-20) - sc-7847 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TH (C-20): sc-7847. Western blot analysis of TH expression in PC-12 whole cell lysate.

TH (F-11) - sc-25269 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TH (F-11): sc-25269. Western blot analysis of TH expression in rat adrenal gland extract.

TH (H-196) - sc-14007 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TH (H-196): sc-14007. Immunofluorescence staining of methanol-fixed PC-12 cells showing cytoplasmic localization.

TH (N-15) - sc-7848 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TH (N-15): sc-7848. Western blot analysis of TH expression in NGF-treated PC-12 whole cell lysate.

TH (TOH A1.1) - sc-47708 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

TH (6A477) - sc-73151 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

TH (3G298) - sc-73152 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-Tyrosine Hydroxylase (phospho S19) antibody - ab195934 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Tyrosine Hydroxylase (phospho S19) antibody (ab195934) at 1/500 dilutionLane 1 : Insulin treated 293 whole cell lysate with antigen-specific peptideLane 2 : Insulin treated 293 whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-Tyrosine Hydroxylase (phospho S19) antibody - ab194785 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of methanol-fixed HeLa cells, labeling Tyrosine Hydroxylase (phospho S19) using ab194785 at a 1/100 dilution.

Anti-Tyrosine Hydroxylase (phospho S19) antibody - ab51194 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human brain tissue using ab51194 (1/50 dilution). Left: without immunizing peptide, Right: with immunizing peptide

Anti-Tyrosine Hydroxylase (phospho S31) antibody - ab195750 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Tyrosine Hydroxylase (phospho S31) antibody (ab195750) at 1/500 dilutionLane 1 : UV treated 293 whole cell lysates with antigen-specific peptideLane 2 : UV treated 293 whole cell lysatesLysates/proteins at 12.5 µg per lane.

Anti-Tyrosine Hydroxylase (phospho S31) antibody - ab194760 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Tyrosine Hydroxylase (phospho S31) antibody (ab194760) at 1/500 dilutionLane 1 : Untreated 293 cell extractLane 2 : Doxorubicin treated 293 cell extract

Anti-Tyrosine Hydroxylase (phospho S31) antibody - ab51197 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human brain tissue using Tyrosine Hydroxylase (phospho-Ser31) antibody (ab51197). Right hand panel represents a negative control where ab51197 was pre-incubated with the immunizing (blocking) peptide.

Anti-Tyrosine Hydroxylase (phospho S40) antibody - ab51206 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
This image shows human brain tissue stained with ab51206 at a dilution of 1/50-1/100. Right hand image: treated with immunising peptide; left hand image: untreated.

Anti-Tyrosine Hydroxylase (phospho S40) antibody - ab131540 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of methanol-fixed HeLa cells labelling Tyrosine Hydroxylase (phospho S40) with ab131540 at 1/100 dilution.

Anti-Tyrosine Hydroxylase antibody - ab76442 from Abcam

Prices $401.00
Sizes 250 µl
Host Chicken
Clonality Polyclonal
Tyrosine hydroxylase-positive neurons (red) in the substantia nigra of a GFP-expressing transgenic mouse using ab76442 at 1/1000 dilution in 2% paraformaldehyde-fixed tissue.

Anti-Tyrosine Hydroxylase antibody - ab137721 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Tyrosine Hydroxylase antibody (ab137721) at 1/1000 dilution + PC-12 whole cell lysate at 30 µg

Anti-Tyrosine Hydroxylase antibody - ab191486 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Tyrosine Hydroxylase antibody (ab191486) at 1/10000 dilution + Human fetal brain lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-Tyrosine Hydroxylase antibody - ab51191 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human brain tissue using ab51191 (1/50 dilution). Left: without immunizing peptide, Right: with immunizing peptide

Anti-Tyrosine Hydroxylase antibody - ab117112 from Abcam

Prices $387.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Tyrosine Hydroxylase antibody (ab117112) at 1/10000 dilutionLane 1 : Mouse Brain Tissue lysate(striatum)Lane 2 : Mouse Brain Tissue lysate(cortex)Lane 3 : Mouse Brain Tissue lysate(substantia nigra)Lane 4 : Mouse Brain Tissue lysate(hippocampus)Lysates/proteins at 30 µg per lane.SecondaryDonkey anti-rabbit HRP cojugated polyclonal at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Tyrosine Hydroxylase antibody - ab93291 from Abcam

Prices $378.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
IHC image of Tyrosine Hydroxylase staining in human cerebral cortex formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab93291, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.
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