HMBS

Gene Symbol	HMBS
Entrez Gene	3145
Alt Symbol	PBG-D, PBGD, PORC, UPS
Species	Human
Gene Type	protein-coding
Description	hydroxymethylbilane synthase
Other Description	porphobilinogen deaminase|porphyria, acute; Chester type|pre-uroporphyrinogen synthase|uroporphyrinogen I synthase|uroporphyrinogen I synthetase
Swissprots	G3V1P4 Q16012 P08396 A8K2L0 G5EA58 P08397
Accessions	AAA60028 AAA60029 AAA60030 AAC60602 ABI36594 AHW82961 BAA01463 BAA02216 BAD36778 BAG71787 CAA48156 EAW67447 EAW67448 EAW67449 EAW67450 P08397 AK000628 AK131072 AK290275 BAF82964 AK309544 AK310343 AW139390 BC000520 AAH00520 BC008149 AAH08149 BC019323 AAH19323 BF210364 BQ020524 BX647328 CB128006 D28419 BAA05785 HQ448217 ADQ32697 HQ731552 ADX60069 M60888 X04217 CAA27801 X04808 CAA28499 XM_005271531 XP_005271588 XM_005271532 XP_005271589 XM_005271533 XP_005271590 XM_011542796 XP_011541098 NM_000190 NP_000181 NM_001024382 NP_001019553 NM_001258208 NP_001245137 NM_001258209 NP_001245138
Function	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Subcellular Location	Cytoplasm {ECO:0000305}.
Tissue Specificity	Isoform 1 is ubiquitously expressed. Isoform 2 is found only in erythroid cells. {ECO:0000269|PubMed:3422427}.
Top Pathways	Porphyrin and chlorophyll metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PBGD CRISPR/Cas9 KO Plasmid (h) - sc-404924 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PBGD HDR Plasmid (h) - sc-404924-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PBGD Double Nickase Plasmid (h) - sc-404924-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PBGD Double Nickase Plasmid (h2) - sc-404924-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PBGD CRISPR Activation Plasmid (h) - sc-404924-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PBGD CRISPR Activation Plasmid (h2) - sc-404924-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PBGD Lentiviral Activation Particles (h) - sc-404924-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PBGD Lentiviral Activation Particles (h2) - sc-404924-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PBGD siRNA (h) - sc-45702 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PBGD shRNA Plasmid (h) - sc-45702-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PBGD shRNA (h) Lentiviral Particles - sc-45702-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HMBS RNAi - H00003145-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU058501 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10155 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10155 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02568 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr02568

HMBS siRNA (Human) - CRH2146 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

HMBS RNAi - H00003145-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

HMBS - MBS8225618 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human HMBS (NM_000190.3) - SHH313193 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human HMBS(NM_001024382.1) - SHH124661 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human HMBS(NM_000190.3) - SHH124679 from Creative biogene Category siRNA Species Reactivities Human

Human HMBS siRNA - orb262648 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

HMBS shRNA Plasmid (Human) - CHH2146 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

HMBS miRNA 3'UTR clone - MiUTR1H-04597 from Creative biogene Species Reactivities Human

Search more