| Gene Symbol |
KDM4B
|
| Entrez Gene |
23030
|
| Alt Symbol |
JMJD2B, TDRD14B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysine (K)-specific demethylase 4B
|
| Other Description |
jmjC domain-containing histone demethylation protein 3B|jumonji domain containing 2B|jumonji domain-containing protein 2B|lysine-specific demethylase 4B|tudor domain containing 14B
|
| Swissprots |
D6W631 Q9UF40 Q6P3R5 O75274 Q9P1V1 O94953 B9EGN8
|
| Accessions |
AAF31271 EAW69180 EAW69181 EAW69182 EAW69183 O94953 AB020683 BAA74899 AF052144 AK026040 AK126854 BAG54381 AL133622 CAB63748 BC015378 BC040014 BC046167 BC063889 AAH63889 BC136611 AAI36612 BC144292 AAI44293 BF917212 DA379611 DB636535 XM_005259521 XP_005259578 XM_005259522 XP_005259579 XM_011527814 XP_011526116 XM_011527815 XP_011526117 XM_011527816 XP_011526118 XM_011527817 XP_011526119 XM_011527818 XP_011526120 XM_011527819 XP_011526121 XM_011527820 XP_011526122 XM_011527821 XP_011526123 XM_011527822 XP_011526124 XR_936167 NM_015015 NP_055830
|
| Function |
Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00537, ECO:0000269|PubMed:15927959}.
|