NDST1

Gene Symbol NDST1
Entrez Gene 3340
Alt Symbol HSST, MRT46, NST1
Species Human
Gene Type protein-coding
Description N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
Other Description HSNST 1|N-HSST 1|N-heparan sulfate sulfotransferase 1|NDST-1|[Heparan sulfate]-glucosamine N-sulfotransferase 1|bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1|glucosaminyl N-deacetylase/N-sulfotransferase 1|heparan sulfate-N-deacetylase/N-sulfotransferase
Swissprots Q96E57 P52848
Accessions EAW61720 EAW61721 EAW61722 P52848 AB209107 BAD92344 AK292448 BAF85137 AK293746 BAH11586 BC012888 AAH12888 BC015828 ES315645 U17970 AAA67765 U18918 AAA75281 U18932 U36600 AAC27354 XM_005268433 XP_005268490 XM_005268434 XP_005268491 XM_005268435 XP_005268492 XM_005268436 XP_005268493 XM_005268437 XP_005268494 XM_005268438 XP_005268495 XM_005268439 XP_005268496 XM_005268441 XP_005268498 XM_005268442 XP_005268499 XM_006714782 XP_006714845 XM_006714783 XP_006714846 XM_011537638 XP_011535940 XR_245854 NM_001301063 NP_001287992 NM_001543 NP_001534
Function Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L- selectin ligands, thereby playing a role in inflammatory response. {ECO:0000269|PubMed:10758005, ECO:0000269|PubMed:12634318}.
Subcellular Location Golgi apparatus membrane {ECO:0000269|PubMed:9230113}; Single-pass type II membrane protein {ECO:0000269|PubMed:9230113}.
Tissue Specificity Widely expressed. Expression is most abundant in heart, liver and pancreas.
Top Pathways Glycosaminoglycan biosynthesis - heparan sulfate / heparin

NDST1 CRISPR/Cas9 KO Plasmid (h) - sc-404078 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NDST1 HDR Plasmid (h) - sc-404078-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NDST1 Double Nickase Plasmid (h) - sc-404078-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NDST1 Double Nickase Plasmid (h2) - sc-404078-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NDST1 CRISPR Activation Plasmid (h) - sc-404078-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NDST1 CRISPR Activation Plasmid (h2) - sc-404078-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NDST1 Lentiviral Activation Particles (h) - sc-404078-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NDST1 Lentiviral Activation Particles (h2) - sc-404078-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NDST1 siRNA (h) - sc-40761 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NDST1 shRNA Plasmid (h) - sc-40761-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NDST1 shRNA (h) Lentiviral Particles - sc-40761-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

N-Deacetylase/N-Sulfotransferase 1/NDST1 RNAi - H00003340-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU045681 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15130 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15130 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NDST1 siRNA (Human) - CRH2277 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NDST1 (NM_001543.4) - SHH350412 from Creative biogene

Category siRNA
Species Reactivities Human

NDST1 shRNA Plasmid (Human) - CHH2277 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NDST1 miRNA 3'UTR clone - MiUTR4H-TG05905 from Creative biogene

Species Reactivities Human
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