STAMBP

Gene Symbol	STAMBP
Entrez Gene	10617
Alt Symbol	AMSH, MICCAP
Species	Human
Gene Type	protein-coding
Description	STAM binding protein
Other Description	STAM-binding protein|associated molecule with the SH3 domain of STAM|endosome-associated ubiquitin isopeptidase
Swissprots	D6W5H7 Q3MJE7 B5M0B6 O95630
Accessions	AAX88908 CAC36455 CCQ43357 EAW99714 EAW99715 EAW99716 O95630 AF052135 AK023768 BC007682 AAH07682 BC065574 AAH65574 BC101467 AAI01468 BC101469 AAI01470 BF203378 BM478027 BQ929694 CX758449 DB477012 DN919763 DQ892616 ABM83542 DQ895856 ABM86782 DR158757 EU927390 ACH57452 U73522 AAD05037 XM_005264088 XP_005264145 XM_005264091 XP_005264148 XM_011532483 XP_011530785 XM_011532484 XP_011530786 XM_011532485 XP_011530787 XR_939651 NM_006463 NP_006454 NM_201647 NP_964010 NM_213622 NP_998787
Function	Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. {ECO:0000250, ECO:0000269|PubMed:10383417, ECO:0000269|PubMed:11483516, ECO:0000269|PubMed:15314065, ECO:0000269|PubMed:17261583, ECO:0000269|PubMed:23542699}.
Subcellular Location	Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome.
Tissue Specificity	Ubiquitously expressed.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

STAMBP-Over-expression-Lysate - LY14679a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

STAMBP 293T Cell Transient Overexpression Lysate(Denatured) - H00010617-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

STAMBP overexpression lysate - LY403869 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

STAMBP overexpression lysate - LY404497 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

STAMBP overexpression lysate - LY416628 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

STAMBP overexpression lysate - LY431018 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

STAMBP 293 Cell Lysate - 403368 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

STAMBP 293 Cell Lysate - 407764 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

AMSH/STAMBP Overexpression Lysate (Native) - NBL1-16511 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

AMSH/STAMBP Overexpression Lysate (Native) - NBL1-16512 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

STAMBP (h): 293T Lysate - sc-117052 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

STAMBP (h2): 293T Lysate - sc-159791 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

STAMBP (h3): 293T Lysate - sc-170434 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

STAMBP Over-expression Lysate Product - GWB-A6EA33 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

STAMBP Over-expression Lysate Product - GWB-531080 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

AMSH/STAMBP Overexpression Lysate (Denatured) - H00010617-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human STAMBP Knockdown Stable Cell Line - CSC-DC015266 from Creative biogene Category Cell Line Species Human

STAMBP Knockout Cell Line-HeLa - CSC-RT1979 from Creative biogene Category Cell Line Species Human

STAMBP KO Cell Lysate-HeLa - CLKO-1839 from Creative biogene Category Cell Lysate

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