| Gene Symbol | UROS |
|---|---|
| Entrez Gene | 7390 |
| Alt Symbol | UROIIIS |
| Species | Human |
| Gene Type | protein-coding |
| Description | uroporphyrinogen III synthase |
| Other Description | hydroxymethylbilane hydrolyase|uroporphyrinogen-III cosynthase|uroporphyrinogen-III synthase |
| Swissprots | B2RC13 Q9H2T1 P10746 D3DRF7 |
| Accessions | EAW49221 EAW49222 EAW49223 EAW49224 EAW49225 EAW49226 EAW49227 EAW49228 EAW49229 P10746 AF230665 AAG36795 AK314896 BAG37410 BC002573 AAH02573 BC004338 AAH04338 DQ891936 ABM82862 DQ895123 ABM86049 DR156879 J03824 AAA60273 XM_005270137 XP_005270194 XM_005270138 XP_005270195 XM_005270139 XP_005270196 XM_005270140 XP_005270197 XM_005270141 XP_005270198 XM_006717960 XP_006718023 XM_011540126 XP_011538428 XM_011540127 XP_011538429 XR_246103 XR_945809 XR_945810 NM_000375 NP_000366 |
| Function | Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme). |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:11112350}. |
| Top Pathways | Porphyrin and chlorophyll metabolism |