| Gene Symbol |
NFATC2
|
| Entrez Gene |
4773
|
| Alt Symbol |
NFAT1, NFATP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
|
| Other Description |
NF-ATc2|NFAT pre-existing subunit|NFAT transcription complex, preexisting component|T cell transcription factor NFAT1|T-cell transcription factor NFAT1|nuclear factor of activated T-cells, cytoplasmic 2|nuclear factor of activated T-cells, preexisting component|preexisting nuclear factor of activated T-cells 2
|
| Swissprots |
Q9UJR2 B5B2P2 Q13469 B5B2N8 Q9NQH3 Q13468 Q5TFW7 B5B2N9 B5B2P0 B5B2P3 Q9NPX6 Q5TFW8
|
| Accessions |
EAW75602 EAW75603 Q13469 AK025758 AK226146 AK304147 BAH14117 AY927566 BC136418 AAI36419 BC144074 AAI44075 BE674599 BF914609 BM463165 BU429325 CD300621 CF136470 CR993438 EU887573 ACG55593 EU887574 ACG55594 EU887575 ACG55595 EU887576 ACG55596 EU887577 ACG55597 EU887578 ACG55598 EU887579 ACG55599 EU887580 ACG55600 U43341 AAC50886 U43342 AAC50887 Z36756 XM_011528824 XP_011527126 XM_011528825 XP_011527127 XM_011528826 XP_011527128 NM_001136021 NP_001129493 NM_001258292 NP_001245221 NM_001258294 NP_001245223 NM_001258295 NP_001245224 NM_001258296 NP_001245225 NM_001258297 NP_001245226 NM_012340 NP_036472 NM_173091 NP_775114
|
| Function |
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway. {ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
|
| Tissue Specificity |
Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas. Isoform 1 is highly expressed in the small intestine, heart, testis, prostate, thymus, placenta and thyroid. Isoform 3 is highly expressed in stomach, uterus, placenta, trachea and thyroid. {ECO:0000269|PubMed:8668213}.
|
| Top Pathways |
Wnt signaling pathway, Osteoclast differentiation, B cell receptor signaling pathway, HTLV-I infection, T cell receptor signaling pathway
|