| Gene Symbol |
EEF1A1
|
| Entrez Gene |
1915
|
| Alt Symbol |
CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, HNGC:16303, LENG7, PTI1, eEF1A-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation elongation factor 1 alpha 1
|
| Other Description |
CTCL tumor antigen|EF-1-alpha-1|EF1a-like protein|cervical cancer suppressor 3|elongation factor 1 alpha subunit|elongation factor 1-alpha 1|elongation factor Tu|eukaryotic elongation factor 1 A-1|eukaryotic translation elongation factor 1 alpha 1-like 14|glucocorticoid receptor AF-1 specific elongation factor|leukocyte receptor cluster (LRC) member 7|leukocyte receptor cluster member 7|prostate tumor-inducing protein 1|translation elongation factor 1 alpha 1-like 14
|
| Swissprots |
Q6IQ15 P68104
|
| Accessions |
AAA52343 CBJ05783 CBJ21235 EAW48759 P68104 AF174496 AAF36537 AF328730 AAN09722 AF397403 AAK93966 AJ420488 AK024888 AK026650 AK055058 BAG51457 AK058051 AK058082 AK058163 AK098510 AK098518 AK098587 AK098623 AK127384 BAG54498 AK222515 BAD96235 AK222519 BAD96239 AK222523 BAD96243 AK222551 BAD96271 AK222982 BAD96702 AK223030 BAD96750 AK223042 BAD96762 AK223046 BAD96766 AK289374 BAF82063 AK289442 BAF82131 AK290691 BAF83380 AK292639 BAF85328 AK297878 BAG60202 AK300922 BAG62554 AK304214 BAG65087 AK315827 BAF98718 AY043301 AAK95378 BC008587 AAH08587 BC009733 AAH09733 BC009875 AAH09875 BC010735 AAH10735 BC012509 AAH12509 BC012891 AAH12891 BC014224 AAH14224 BC014377 AAH14377 BC014892 AAH14892 BC018150 AAH18150 BC018641 AAH18641 BC018850 BC019050 BC019669 BC020477 BC021686 AAH21686 BC022412 AAH22412 BC028674 AAH28674 BC029337 BC029343 BC029997 BC035877 BC038339 AAH38339 BC038897 BC057391 AAH57391 BC063511 AAH63511 BC065761 AAH65761 BC066893 AAH66893 BC066894 BC070131 AAH70131 BC070500 AAH70500 BC071619 AAH71619 BC071727 AAH71727 BC071741 AAH71741 BC071841 AAH71841 BC072385 AAH72385 BC082268 AAH82268 BC094687 AAH94687 BC111051 AAI11052 DQ185041 ABD14421 DQ867534 ABI74620 DQ891450 ABM82376 DQ894629 ABM85555 EF219140 EF362804 ABO30531 M27364 AAA52344 M29548 AAA52367 X03558 CAA27245 X03689 CAA27325 X16869 CAA34756 XM_011535514 XP_011533816 NM_001402 NP_001393 NM_001403
|
| Function |
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. {ECO:0000269|PubMed:17177976}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery. Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens.
|
| Tissue Specificity |
Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle.
|
| Top Pathways |
RNA transport, Legionellosis
|
![Western Blot: eEF1A1 Overexpression Lysate (Adult Normal) [NBL1-10121] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for eEF1A1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3854_eEF1A1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10121-img0002.jpg)