Gene Symbol | H2AFJ |
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Entrez Gene | 55766 |
Alt Symbol | H2AJ |
Species | Human |
Gene Type | protein-coding |
Description | H2A histone family, member J |
Other Description | H2a/j|buforin I|histone H2A.J |
Swissprots | Q9NV63 Q9BTM1 |
Accessions | EAW96326 EAW96327 Q9BTM1 AK001765 BAA91894 AK303301 BAG64375 AL133626 BC003602 AAH03602 BM689354 BQ438653 BU594879 DA808847 DB084616 HQ447950 ADQ32434 NM_177925 NP_808760 NR_027716 NM_018267 |
Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Subcellular Location | Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. |
Top Pathways | Systemic lupus erythematosus, Alcoholism |
Histone H2A.J CRISPR/Cas9 KO Plasmid (h) - sc-412598 from Santa Cruz Biotechnology
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Histone H2A.J HDR Plasmid (h) - sc-412598-HDR from Santa Cruz Biotechnology
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Histone H2A.J Double Nickase Plasmid (h) - sc-412598-NIC from Santa Cruz Biotechnology
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Histone H2A.J Double Nickase Plasmid (h2) - sc-412598-NIC-2 from Santa Cruz Biotechnology
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Histone H2A.J CRISPR Activation Plasmid (h) - sc-412598-ACT from Santa Cruz Biotechnology
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Histone H2A.J CRISPR Activation Plasmid (h2) - sc-412598-ACT-2 from Santa Cruz Biotechnology
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Histone H2A.J Lentiviral Activation Particles (h) - sc-412598-LAC from Santa Cruz Biotechnology
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Histone H2A.J Lentiviral Activation Particles (h2) - sc-412598-LAC-2 from Santa Cruz Biotechnology
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Histone H2A.J siRNA (h) - sc-105521 from Santa Cruz Biotechnology
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Histone H2A.J shRNA Plasmid (h) - sc-105521-SH from Santa Cruz Biotechnology
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Histone H2A.J shRNA (h) Lentiviral Particles - sc-105521-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN9839 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9839 from Sigma-Aldrich
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H2AFJ siRNA (Human) - CRJ0904 from Cohesion Biosciences
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H2AFJ RNAi - H00055766-R02 from Novus Biologicals
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H2AFJ - MBS827833 from MyBioSource
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shRNA set against Human H2AFJ (NM_177925.2) - SHH309818 from Creative biogene
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shRNA set against Human H2AFJ(NM_177925.2) - SHH112043 from Creative biogene
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H2AFJ shRNA Plasmid (Human) - CHJ0904 from Cohesion Biosciences
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H2AFJ miRNA 3'UTR clone - MiUTR1H-04349 from Creative biogene
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